I have always believed that the traditions, rivalries and other aspects of college sports are second to none. Although the new era of NIL, transfer portals and continuous conference realignment threatens a lot of that, much remains. How teams fare against one another consistently, or any other trends that form in long-running series, should be considered when it comes to handicapping games. 

We haven’t had the time or resources to put together a daily college basketball analytics report yet, but I hope to do so soon. With that in mind, and with college football having just ended its season on Monday night, it’s a great time to share the best head-to-head opportunities that come up on a day-to-day basis on the college hoops board, particularly in the heart of conference play. 

Logically, every team in every league has opponents they match up better or worse against. It can be because of strength, size, location, or simply good old-fashioned luck. Bettors who don’t consider this aspect in handicapping games are leaving a huge void. In college basketball, it seems to be of particular importance, as some head-to-head trends that have formed over recent years uncover what have turned into extremely lopsided series. This can be because of talent differences, size of crowds and intensity of the rivalry, among other things.

Below you will find 40 top college basketball head-to-head series between conference foes that have been particularly one-sided of late. The next chances to wager start as early as Wednesday, January 21, and there are several games lined up for this weekend. With multiple games left for some of the trends, these angles give bettors 50 nice opportunities to consider the rest of the way. Bookmark this page and come back to it regularly throughout the rest of the season.

* TULSA is 4-6 SU but 9-0 ATS vs. MEMPHIS since Jan. 30, 2019
Next wagering chance(s): Jan. 21 at Tulsa

* Favorites are 22-2 SU and 19-5 ATS in the IDAHO STATE-MONTANA STATE series since Jan. 26, 2013
Next wagering chance(s): Jan. 22 at Montana State, Feb. 21 at Idaho State

* Underdogs are 10-10 SU and 14-5 ATS in the MERCER-WOFFORD series since Feb. 4, 2017
Next wagering chance(s): Jan. 24 at Wofford

* Favorites are 18-4 SU and ATS in the NORTH CAROLINA-VIRGINIA series since Jan. 6, 2013
Next wagering chance(s): Jan. 24 at Virginia

* Favorites are 12-1 SU and 11-1 ATS in the ST. JOHN’S-XAVIER series since March 9, 2019
Next wagering chance(s): Jan. 24 at Xavier, Feb. 9 at St. John’s

* Home teams are 17-3 SU and ATS in the MINNESOTA-NEBRASKA series since Jan. 29, 2013
Next wagering chance(s): Jan. 24 at Minnesota

* Underdogs are 12-14 SU but 19-6 ATS in the WISCONSIN MILWAUKEE-WRIGHT STATE series since Jan. 30, 2014
Next wagering chance(s): Jan. 30 at Wisconsin-Milwaukee

* Underdogs are 12-8 SU and 15-4 ATS in the MIAMI OHIO-NORTHERN ILLINOIS series since Jan. 9, 2013
Next wagering chance(s): Jan. 31 at Miami Ohio

* Underdogs are 13-13 SU and 21-5 ATS in the OKLAHOMA-TEXAS series since Jan. 21, 2013
Next wagering chance(s): Jan. 31 at Oklahoma, March 7 at Texas

* CLEMSON is 14-0 SU and 13-0 ATS vs. PITTSBURGH since Jan. 10, 2015
Next wagering chance(s): Jan. 31 at Clemson

* EASTERN ILLINOIS is just 9-18 SU and 8-19 ATS vs. SOUTHEAST MISSOURI STATE since Feb. 9, 2013
Next wagering chance(s): Jan. 31 at Eastern Illinois

* FLORIDA GULF COAST is 12-1 SU and ATS vs. JACKSONVILLE since March 3, 2015
Next wagering chance(s): Jan. 31 at Jacksonville, Feb. 19 at Florida Gulf Coast

* GONZAGA is 26-10 SU and 24-11 ATS vs. ST. MARY’S since Feb. 14, 2013
Next wagering chance(s): Jan. 31 at Gonzaga, Feb. 28 at St. Mary’s

* Favorites are 16-1 SU and 14-3 ATS in the BRADLEY-VALPARAISO series since Jan. 3, 2018
Next wagering chance(s): Feb. 3 at Bradley, Feb. 18 at Valparaiso

* SANTA CLARA is 20-7 SU and 20-7 ATS vs. PACIFIC since Dec. 15, 2012
Next wagering chance(s): Feb. 4 at Pacific

* Underdogs are 17-11 SU and 23-5 ATS in the IDAHO STATE-NORTH ARIZONA series since Jan. 19, 2013
Next wagering chance(s): Feb. 5 at Idaho State

* Favorites are 16-3 SU and 15-3 ATS in the MARYLAND-OHIO STATE series since 12/4/2013
Next wagering chance(s): Feb. 5 at Maryland

* Road teams are 15-11 SU and 21-5 ATS in the MARIST-RIDER series since Feb. 3, 2013
Next wagering chance(s): Feb. 5 at Marist

* Underdogs are 9-11 SU but 13-4 ATS in the INDIANA-WISCONSIN series since Jan. 15, 2013
Next wagering chance(s): Feb. 7 at Indiana

* Favorites are 17-3 SU and 16-4 ATS in the CREIGHTON-SETON HALL series since March 10, 2016
Next wagering chance(s): Feb. 7 at Creighton

* Favorites are 13-3 SU and ATS in the DREXEL-ELON series since Jan. 19, 2017
Next wagering chance(s): Feb. 7 at Elon

* IOWA STATE is 6-5 SU and 11-0 ATS vs. BAYLOR since Jan. 2, 2021
Next wagering chance(s): Feb. 7 at Iowa State

* WEBER STATE is 9-0 SU and ATS hosting NORTHERN ARIZONA since Jan. 4, 2018
Next wagering chance(s): Feb. 7 at Weber State

* Road teams are 8-7 SU and 14-1 ATS in the GEORGE MASON-SAINT JOSEPH’S series since Jan. 11, 2014
Next wagering chance(s): Feb. 7 at George Mason, Feb. 25 at Saint Joseph’s

* Home teams are 21-4 SU and 19-6 ATS in the SIENA-ST. PETER’S series since Jan. 13, 2013
Next wagering chance(s): Feb. 7 at St. Peter’s, Feb. 22 at Siena

* UNC-WILMINGTON is 19-9 SU and 23-5 ATS vs. COLLEGE OF CHARLESTON since Jan. 22, 2014
Next wagering chance(s): Feb. 9 at College of Charleston, Feb. 28 at UNC-Wilmington

* Road teams are 6-7 SU but 13-0 ATS in the UC DAVIS-LONG BEACH STATE series since Feb. 16, 2019
Next wagering chance(s):  2/14 at UC Davis, March 5 at Long Beach State

* Road teams are 11-7 SU and 16-2 ATS in the DETROIT-YOUNGSTOWN STATE series since Feb. 4, 2017
Next wagering chance(s): Feb. 15 at Detroit

* SAN DIEGO is 3-6 SU but 9-0 ATS at SAN FRANCISCO since Dec. 29, 2016
Next wagering chance(s): Feb. 15 at San Francisco

* Home teams are 6-6 SU but 11-1 ATS in the GONZAGA-PACIFIC series since Dec. 28, 2017
Next wagering chance(s): Feb. 21 at Gonzaga

* Home teams are 16-5 SU but 18-3 ATS in the NORTHERN  KENTUCKY-YOUNGSTOWN STATE series since 1/14/2016
Next wagering chance(s): Feb. 21 at Youngstown State

* OAKLAND is 7-2 SU and 9-0 ATS vs. WISCONSIN-MILWAUKEE since Dec. 29, 2022
Next wagering chance(s): Feb. 22 at Oakland

* LAMAR is 7-4 SU and 11-0 ATS vs. NICHOLLS STATE since Feb. 12, 2020
Next wagering chance(s): Feb. 23 at Lamar

* COLORADO STATE is 10-1 SU and 11-0 ATS hosting FRESNO STATE since Jan. 11, 2014
Next wagering chance(s): Feb. 24 at Colorado State

* Home teams are 10-3 SU but 12-1 ATS in the AIR FORCE-SAN JOSE STATE series since Jan. 25, 2020
Next wagering chance(s): Feb. 24 at Air Force

* TOLEDO is 18-3 SU and 17-4 ATS vs. OHIO U since Feb. 12, 2014
Next wagering chance(s): Feb. 28 at Ohio U

* Underdogs are 3-10 SU but 11-2 ATS in the FARLEIGH DICKINSON-LONG ISLAND series since Feb. 21, 2020
Next wagering chance(s): Feb. 28 at Long Island

* Favorites are 12-1 SU and ATS in the ARKANSAS-FLORIDA series since March 10, 2016
Next wagering chance(s): Feb. 28 at Florida

* Road teams are 15-5 SU and 17-3 ATS in the HAWAII-UC RIVERSIDE series since Jan. 14, 2016
Next wagering chance(s): March 6 at Hawaii

* OHIO U is 12-0 SU and 11-0 ATS hosting MIAMI OHIO since March 12, 2014
Next wagering chance(s): March 6 at Ohio U

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Steve Makinen
As one of the original founders of StatFox, Steve Makinen has been in the business of sports betting and data analysis for almost 25 years now. In his time in the industry, Steve has worked in a variety of capacities on both sides of the betting counter, from his early days of developing the StatFox business, to almost a decade of oddsmaking consulting for one of the world's leading sportsbooks, to his last seven years as Point Spread Weekly and Analytics Director with VSiN. Steve has always believed that number crunching and handicapping through foundational trends and systems is the secret to success and he shares this data with VSiN readers on a daily basis for all of the major sports.