College Football Head-to-Head Betting Trends for the 2025 Season:
One of the many pieces of information that I utilize each week in preparing my college football wagering list is the head-to-head series trends between opponents. There are certain opponents that consistently bring out the best or worst in teams. There are also certain rivalries in which home-field advantage means a ton or nothing. That’s just the nature of such rivalry series. Let’s take a look at what I found to be 135 of the more intriguing head-to-head series trends that will be impacting the 2025 college football season. Pin these to your calendar and jump on them when they arise, because trust me, most of them will likely continue.
If you don’t bookmark this piece, which I would suggest, don’t fret, as these will be republished weekly in our upcoming College Football Analytics Reports, a can’t-miss feature for any regular CFB bettor.
Bet these games now as they stand at various sportsbooks or wait till the week or day arrives. Note that these games begin as early as…
Week 1
Friday, August 29, 2025
WESTERN MICHIGAN at MICHIGAN STATE
Trend: HOME TEAMS are 6-1 ATS in the last seven of the in-state rivalry between Western Michigan and Michigan State
Saturday, August 30, 2025
CALIFORNIA at OREGON STATE
Trend: Over the total is 8-2-1 in the last 11 of the CAL-OSU series, including 5-1 in the last six in Corvallis
Week 2
Saturday, September 6, 2025
KANSAS at MISSOURI
Trend: Underdogs are on an 8-2 ATS run in the last 10 of the Kansas-Missouri rivalry
OLE MISS at KENTUCKY
Trend: Underdogs have won the last five games, both SU and ATS, in the Ole Miss-Kentucky SEC series
IOWA at IOWA STATE
Trend: Under the total is 15-5 in the last 20 years of the Iowa-Iowa State rivalry
Week 3
Thursday, September 11, 2025
NC STATE at WAKE FOREST
Trend: Home teams are on a 19-6 ATS run in WF-NCST head-to-head series since 2000 *although two straight road covers*
Saturday, September 13, 2025
FLORIDA ATLANTIC at FLORIDA INTERNATIONAL
Trend: FAU is 7-0 SU and ATS in the last seven of the rivalry with FIU
BUFFALO at KENT STATE
Trend: Favorites are 7-2 ATS in the last nine of the BUFF-KSU series
CLEMSON at GEORGIA TECH
Trend: CLEMSON is on a 12-0 SU and 9-2-1 ATS surge versus GA Tech
VANDERBILT at SOUTH CAROLINA
Trend: SOUTH CAROLINA is on runs of 16-0 SU and 8-1-1 ATS versus Vanderbilt
GEORGIA at TENNESSEE
Trend: GEORGIA is on an 8-1 SU and ATS run versus Tennessee
ARKANSAS at OLE MISS
Trend: ARKANSAS is on a 10-2 ATS run overall versus Ole Miss
Week 4
Saturday, September 20, 2025
FLORIDA at MIAMI (FL)
Trend: MIAMI (FL) is on a 6-2 SU and 7-1 ATS run vs. Florida
WEST VIRGINIA at KANSAS
Trend: Over the total is 7-1 in the last eight of the WVU-KU head-to-head series
WASHINGTON at WASHINGTON STATE
Trend: WASHINGTON is 8-3 SU and 9-2 ATS in the last 11 in-state visits to Pullman
SYRACUSE at CLEMSON
Trend: Under the total is 9-2 in the Syracuse-Clemson head-to-head series since 2013
SOUTH CAROLINA at MISSOURI
Trend: Under the total is 10-3 in the last 13 of the MIZZOU-SC head-to-head series
Trend: MISSOURI is on a 5-1 SU and 6-0 ATS surge versus SC
SMU at TCU
Trend: Road teams are on an 8-2 ATS run in the SMU-TCU rivalry
Week 5
Saturday, September 27, 2025
ARKANSAS STATE at LA MONROE
Trend: ARKANSAS STATE is on a 15-0 SU and ATS run versus LA Monroe
CONNECTICUT at BUFFALO
Trend: CONNECTICUT is 9-1 SU and 8-2 ATS in the last 10 head-to-head meetings with Buffalo
TULANE at TULSA
Trend: Favorites are on an absurd 18-1 SU and 17-2 ATS surge in the Tulane-Tulsa head-to-head series
BOWLING GREEN at OHIO
Trend: Favorites are 10-1 SU and 9-2 ATS in the last 11 of the BGSU-OHIO head-to-head series
BAYLOR at OKLAHOMA STATE
Trend: OKLAHOMA STATE is 10-2 SU and ATS in the last 12 games hosting Baylor
ALABAMA at GEORGIA
Trend: Underdogs are 6-5 SU and 9-2 ATS in the last 13 of the Bama-UGA head-to-head series
Trend: Over the total is 10-3 in the Bama-UGA head-to-head series since 2002
KENTUCKY at SOUTH CAROLINA
Trend: Under the total is 9-1 in the last 10 of the South Carolina-Kentucky rivalry
LSU at OLE MISS
Trend: Home teams are on an 11-1 ATS surge in the Ole Miss-LSU series
NEW MEXICO STATE at NEW MEXICO
Trend: NEW MEXICO STATE is on an 8-2 ATS run versus New Mexico, including 7-1 ATS in the last eight visits to Albuquerque
Week 6
Saturday, October 4, 2025
NEW MEXICO at SAN JOSE STATE
Trend: SAN JOSE STATE has covered all six head-to-head meetings with New Mexico since 2006
WISCONSIN at MICHIGAN
Trend: Over the total is 8-2 in the last 10 of the UW-UM head-to-head series
UNLV at WYOMING
Trend: Over the total is 7-0-1 in the last eight of the UNLV-WYO head-to-head series in Laramie
KANSAS STATE at BAYLOR
Trend: Underdogs are 11-3 ATS in the last 14 head-to-head matchups between KSU-BU, including 7-1 ATS in the last eight in Waco
SOUTH ALABAMA at TROY
Trend: Under the total is 9-3-1 in the last 13 of the USA-Troy head-to-head series
NEVADA at FRESNO STATE
Trend: ROAD TEAMS are 11-2-1 ATS in L14 of FSU-NEV rivalry
MIAMI (OH) at NORTHERN ILLINOIS
Trend: MIAMI (OH) is 9-1 ATS in the last 10 vs. Northern Illinois
MIAMI (FL) at FLORIDA STATE
Trend: Road teams are on a 15-4 ATS surge in the FSU-MIA ACC series
Trend: Under the total is 6-1 in the last seven of the head-to-head series in Tallahassee
Week 7
Thursday, October 9, 2025
EAST CAROLINA at TULANE
Trend: Under the total is 12-3 in the last 15 of the ECU-Tulane head-to-head series
Saturday, October 11, 2025
PURDUE at MINNESOTA
Trend: Underdogs are 7-4 SU and 9-2 ATS in the last 11 of the PUR-MINN head-to-head rivalry
TCU at KANSAS STATE
Trend: Under the total is 8-1 in the last nine of the TCU-KSU head-to-head series
BALL STATE at WESTERN MICHIGAN
Trend: Over the total is 8-1 in the BALL ST-WMU head-to-head series since 2016
NEW MEXICO at BOISE STATE
Trend: Under the total is 7-0 in the last seven of the UNM-Boise State head-to-head MW rivalry in Boise
AIR FORCE at UNLV
Trend: Over the total is 11-3 in the last 14 of the AF-UNLV head-to-head series
MIAMI (OH) at AKRON
Trend: Road teams are 10-2 ATS in the last 12 of Miami (OH)-Akron head-to-head series
CLEMSON at BOSTON COLLEGE
Trend: Road teams are 8-2-1 ATS in the CLEM-BC head-to-head series
VIRGINIA TECH at GEORGIA TECH
Trend: Road teams are on a 14-3 ATS surge in the GT-VT ACC series
Week 8
Friday, October 17, 2025
SAN JOSE STATE at UTAH STATE
Trend: UTAH STATE is 10-1 SU and 9-2 ATS in the last 11 head-to-head meetings with SJSU
LOUISVILLE at MIAMI (FL)
Trend: Favorites are 7-0 ATS in the LOU-MFL head-to-head series since 2006
Saturday, October 18, 2025
WYOMING at AIR FORCE
Trend: WYOMING is 13-2 ATS in the last 15 head-to-head matchups with Air Force
PURDUE at NORTHWESTERN
Trend: Road teams are 9-4 SU and 10-2-1 ATS in the last 13 of the PUR-NW head-to-head series
UT-SAN ANTONIO at NORTH TEXAS
Trend: Home teams are 10-2 SU and 10-1-1 ATS in the last 12 of the UTSA-UNT head-to-head in-state rivalry
PITTSBURGH at SYRACUSE
Trend: Under the total is 10-3 in the last 13 of the PITT-SU head-to-head series, including 6-0 in the last six at Syracuse
NORTHERN ILLINOIS at OHIO
Trend: Underdogs are 9-1 ATS in the last 10 of the NIU-OHIO head-to-head series
SOUTHERN MISS at LA LAFAYETTE
Trend: SOUTHERN MISS is 6-1 SU and 7-0 ATS in all seven matchups with LA-Lafayette since 2001
MICHIGAN STATE at INDIANA
Trend: Road teams are 6-1 SU and 7-0 ATS in the last seven of the IND-MSU series
LSU at VANDERBILT
Trend: Road teams are 6-0-1 ATS in the seven head-to-head matchups between LSU and Vandy since 2004
GEORGIA TECH at DUKE
Trend: Underdogs are on a run of 6-4 SU and 8-0-2 ATS in the Duke-GT series
USC at NOTRE DAME
Trend: Favorites are 10-2 ATS in the last 12 of the Notre Dame-USC rivalry
OHIO STATE at WISCONSIN
Trend: Home teams are 7-1-1 ATS in the last nine non-neutral head-to-head matchups between OSU and UW
Week 9
Saturday, October 25, 2025
AUBURN at ARKANSAS
Trend: Over the total is 9-2 in the last 11 of the Arkansas-Auburn set
BOSTON COLLEGE at LOUISVILLE
Trend: Over the total is 8-1 in the BC-UL head-to-head series since 2016
TCU at WEST VIRGINIA
Trend: WEST VIRGINIA is 9-2 ATS in the last 11 head-to-head games versus TCU
COLORADO at UTAH
Trend: Under the total is 6-1 in the last seven of the COL-UTAH head-to-head rivalry in Salt Lake City
OHIO U at EASTERN MICHIGAN
Trend: OHIO U is on a 7-1 SU and ATS run versus Eastern Michigan
OKLAHOMA STATE at TEXAS TECH
Trend: Road teams are 11-3 ATS in the last 14 of the TTU-OSU set
BOWLING GREEN at KENT STATE
Trend: Road teams are 11-2 ATS run in the KSU-BGSU series
TENNESSEE at KENTUCKY
Trend: TENNESSEE is on a 14-4 ATS overall run vs. Kentucky, including a 9-1 ATS surge in Lexington
SOUTH FLORIDA at MEMPHIS
Trend: Road teams are on a 10-0-1 ATS run in the MEM-USF head-to-head series
Week 10
Saturday, November 1, 2025
ARMY at AIR FORCE
Trends: Underdogs are on a 9-0 ATS streak and Under the total has converted in 12 straight in the Air Force-Army rivalry
TEXAS TECH at KANSAS STATE
Trend: KANSAS STATE is 12-1 SU and 10-2-1 ATS in the last 13 head-to-head games with TTU
HAWAII at SAN JOSE STATE
Trend: Road teams are 8-3 SU and 9-2 ATS in the last 11 of the Hawaii-SJSU head-to-head series
INDIANA at MARYLAND
Trend: Over the total is 9-1 in the last 10 of the MARY-IU series, including five straight Overs in College Park
Trend: HOME TEAMS are 8-1 ATS in the last nine of the MARY-IU series
UNLV at NEW MEXICO
Trend: Road teams are 6-1 SU and 7-0 ATS in the last seven of the UNLV-UNM head-to-head Mountain West rivalry, including five outright wins as road underdogs
LA LAFAYETTE at SOUTH ALABAMA
Trend: Under the total is 10-2 in the ULL-USA head-to-head series since 2013
OKLAHOMA ST at KANSAS
Trend: OKLAHOMA STATE is 8-1 SU and 7-1-1 ATS in the last nine versus KU
MICHIGAN STATE at MINNESOTA
Trend: MINNESOTA is 9-1 ATS in the last 10 head-to-head games with MSU
WAKE FOREST at FLORIDA STATE
Trend: Under the total is 7-1 in the last eight of the WF-FL ST head-to-head series in Tallahassee
Saturday, November 1, 2025 (AND Saturday, November 29, 2025)
WASHINGTON STATE versus OREGON STATE
Trend: Over the total is 10-2 in the last 12 of the WaSU-OSU head-to-head series
Week 11
Wednesday, November 5, 2025
NORTHERN ILLINOIS at TOLEDO
Trend: Road teams are 11-2 ATS run in the TOL-NIU series
Friday, November 7, 2025
HOUSTON at UCF
Trend: Road teams have covered eight straight ATS in the UH-UCF head-to-head series
Saturday, November 8, 2025
TEXAS STATE UNIV at LA LAFAYETTE
Trend: LA LAFAYETTE is on a 12-0 SU and 11-1 ATS run versus TSU
FLORIDA STATE at CLEMSON
Trend: Favorites are on a 7-0 SU and 6-1 ATS streak in the Clemson-FSU rivalry
BOWLING GREEN at EASTERN MICHIGAN
Trend: Road teams are 8-1 ATS in the last nine of the BGSU-EMU head-to-head series
UNLV at COLORADO STATE
Trend: COLORADO STATE is 9-2 ATS in the last 11 head-to-head games with UNLV, including seven straight covers when hosting the Rebels
FLORIDA INTERNATIONAL at MIDDLE TENN STATE
Trend: Home teams are 9-3 SU and 10-2 ATS in the last 12 of the FIU-MTSU head-to-head series
UAB at RICE
Trend: Home teams are 10-2 ATS in the last 12 of the UAB-RICE head-to-head series
NEVADA at UTAH STATE
Trend: Home teams are 10-2 ATS in the NEV-USU head-to-head series since 2005
WAKE FOREST at VIRGINIA
Trend: WAKE FOREST is 7-0-1 ATS in the last eight head-to-head games with UVA, including 5-0 ATS as road underdog when visiting Charlottesville
GEORGIA STATE at COASTAL CAROLINA
Trend: Road teams are a perfect 8-0 SU and ATS in the CCU-GSU series since 2017
Week 12
Saturday, November 15, 2025
KANSAS STATE at OKLAHOMA STATE
Trend: Home teams are on a 6-1 SU and 7-0 ATS run in the OKST-KST rivalry
VIRGINIA at DUKE
Trend: VIRGINIA is 8-1 SU and ATS in the last nine head-to-head games with Duke
EASTERN MICHIGAN at BALL STATE
Trend: Road teams are 9-2 ATS in the last 11 of the EMU-BSU head-to-head series
COLORADO STATE at NEW MEXICO
Trend: COLORADO STATE is on a 9-1-1 ATS run versus New Mexico
Trend: Under the total has converted in six straight CSU-UNM head-to-head games
Week 13
Wednesday, November 19, 2025
MIAMI (OH) at BUFFALO
Trend: Favorites are on runs of 23-1 SU and 13-2-1 ATS in head-to-head matchups between Miami (OH) and Buffalo
CENTRAL MICHIGAN at KENT STATE
Trend: Over the total is 6-0 in the CMU-KSU head-to-head MAC series since 2007
Thursday, November 20, 2025
LA LAFAYETTE at ARKANSAS STATE
Trend: Home teams are on a 9-2 SU and ATS surge in the ASU-ULL Sun Belt rivalry
Saturday, November 22, 2025
FLORIDA STATE at NC STATE
Trend: Under the total is 7-1 in the last eight of the FSU-NCST head-to-head series
MICHIGAN STATE at IOWA
Trend: Over the total is 7-1 in the last eight of the MSU-IOWA head-to-head series in Iowa City
SAN JOSE STATE at SAN DIEGO STATE
Trend: Under the total is 8-2 in the last 10 SJSU-SDSU head-to-head matchups
ILLINOIS at WISCONSIN
Trend: Over the total is 7-1 in the last eight of the ILL-WISC head-to-head series in Madison
ARIZONA STATE at COLORADO
Trend: Home teams are 8-1-1 ATS in the ASU-COL head-to-head series since 2013
LA MONROE at TEXAS STATE
Trend: Road teams are 11-2 ATS in the ULM-TSU head-to-head series since 2000
NEW MEXICO at AIR FORCE
Trend: Over the total is 10-1 in the last 11 of the Air Force-New Mexico series
TENNESSEE at FLORIDA
Trend: FLORIDA is on a 5-2 SU and 6-1 ATS versus Tennessee
DUKE at NORTH CAROLINA
Trend: Underdogs are 9-3-1 ATS in the last 13 of the Duke-UNC rivalry
KENTUCKY at VANDERBILT
Trend: Road teams are 7-1 ATS in the last eight of the UK-Vandy head-to-head series
BALL STATE at TOLEDO
Trend: BALL STATE is 8-1 ATS in the last nine visits to Toledo
Trend: Under the total is 10-2 in the last 12 of the BALL STATE-TOLEDO head-to-head series
CALIFORNIA at STANFORD
Trend: Road teams are 12-3-1 ATS in the last 16 of the Stanford-Cal rivalry
Week 14
Friday, November 28, 2025
ARIZONA at ARIZONA STATE
Trend: Over the total is 11-2 in the last 13 games of the ASU-Arizona head-to-head series
OLE MISS at MISSISSIPPI STATE
Trend: Underdogs are on an 8-1-1 ATS run, and Under the total is 11-1 in the last 12 of the Egg Bowl series
BOISE STATE at UTAH STATE
Trend: BOISE STATE is on an 8-0 SU and ATS run vs. Utah State
GEORGIA at GEORGIA TECH
Trend: Road teams are 19-4-1 ATS in the UGA-GA Tech head-to-head in-state rivalry since 2000, including Georgia being a perfect 12-0 SU in Atlanta
AIR FORCE at COLORADO STATE
Trend: Road teams are 8-0 ATS in the AF-CSU head-to-head rivalry since 2016
INDIANA at PURDUE
Trend: Over the total is 8-0 in the last eight of the IND-PUR in-state rivalry in West Lafayette
IOWA at NEBRASKA
Trend: Underdogs are on a 6-0-1 ATS streak in the Nebraska-Iowa series
Saturday, November 29, 2025
WISCONSIN at MINNESOTA
Trend: Road teams are on a 10-1 ATS surge in the MIN-WIS rivalry
CLEMSON at SOUTH CAROLINA
Trend: Road teams are on a 6-1 SU and 7-0 ATS streak in the USC-Clemson head-to-head series
FLORIDA STATE at FLORIDA
Trend: Road teams are 11-2 ATS in the Florida-FSU series since 2011
NORTHWESTERN at ILLINOIS
Trend: Over the total is 11-3-1 ATS in the last 15 of the NW-ILL in-state rivalry
KENTUCKY at LOUISVILLE
Trend: Road teams are 11-5 SU and 13-3 ATS in the UK-UL in-state rivalry since 2008
OREGON at WASHINGTON
Trend: OREGON is 7-1-1 ATS in the last nine visits to UW in Seattle
TOLEDO at CENTRAL MICHIGAN
Trend: Favorites are 15-1 SU and 14-2 ATS in the last 16 of the TOL-CMU head-to-head series
Trend: Under the total is 9-1 in the last 10 of the TOL-CMU head-to-head series
PENN STATE at RUTGERS
Trend: Under the total is 9-1 in the last 10 of the PSU-RUTG head-to-head series
VIRGINIA TECH at VIRGINIA
Trend: VA TECH is 7-1 ATS in the last eight of the in-state rivalry with UVA
FRESNO STATE at SAN JOSE STATE
Trend: Under the total is 7-1 in the last eight of the FSU-SJSU head-to-head series
ALABAMA at AUBURN
Trend: Home teams are on an 8-0 ATS streak in the Iron Bowl rivalry
MISSOURI at ARKANSAS
Trend: Home teams are 9-1-1 ATS in the last 11 of the ARK-MIS series
OHIO STATE at MICHIGAN
Trend: Over the total is 10-1 in the last 11 Michigan-Ohio State games
MICHIGAN STATE vs MARYLAND
Trend: Under the total is 8-1-1 in the MSU-Maryland rivalry since 2014
Week 16
Saturday, December 13, 2025
Army vs. Navy
Trend: Underdogs are 10-4 ATS in the last 14 of the Army-Navy rivalry
