Week 12 of the 2025 college football season is here and our VSiN team is attacking it relentlessly. If you haven’t already, make sure you check out the Week 12 CFB Betting Hub for write-ups and picks from all of our talented analysts. However, I’d love for you to keep reading for my college football best bets and predictions for this exciting Week 12 slate. I’ll probably add some picks as lines move and more information comes out later in the week — and on game day. If I do, I’ll put them on the VSiN Pro Picks page. Don’t miss out on those.
MORE: Check out our Pro Picks page for college football best bets from all of our analysts
Virginia Cavaliers at Duke Blue Devils – 3:30 pm ET
Virginia’s defensive numbers look much better than the offensive ones, but that really shouldn’t matter too much here. Duke is capable of sucking teams into shootouts. The Blue Devils are 4-1 to the Over since the start of conference play, which shouldn’t be surprising when looking at their statistical profile. Duke is ninth in the nation in EPA per play (0.17), with Darian Mensah and the passing offense being the driving force behind that. The Blue Devils are also outside of the top-100 in EPA per play allowed (0.11).
Three of Duke’s last four games have featured a combined score of at least 66 points. That said, don’t be surprised if this game is played in the high 60s. Chandler Morris will be returning to action for the Cavaliers, giving Virginia a good player under center to pick apart the weak Duke secondary. And the Blue Devils should be able to hit some big plays in the passing game, even against a Cavaliers secondary that has been good this year.
The Over is also 173-106 since 2021 in conference games featuring a road team that has gone Under the total by 28 or more points in three consecutive games.
Bet: Over 58.5 (-110)
Texas Longhorns at Georgia Bulldogs – 7:30 pm ET
Texas’ offense has been a little inconsistent this season, but the team is very good defensively. The Longhorns have the 11th-best scoring defense in the nation, allowing only 16.4 points per game. That’s really what makes them appealing in this meeting with the Bulldogs. While Georgia has had some big games this season, the team has also scored 24 or fewer points in three conference games. And overall, Gunner Stockton hasn’t looked like the most dangerous thrower in the world. He can be accurate when targeting open receivers, and he’s also good with his legs. But Texas has the ability to make quarterbacks very uncomfortable — even if the defense did look rather pedestrian against both Mississippi State and Vanderbilt.
Arch Manning also happens to be coming off his best game of the season, throwing for 328 yards with three touchdowns and no picks against Vanderbilt two weeks ago. Now, with two weeks to prepare for a Georgia defense that has been disappointing this season, you’d expect the sophomore to deliver — even in a difficult road environment.
The Bulldogs are also just 21-35-1 against the spread as home favorites under Kirby Smart.
Considering all of that, Texas feels like the right side in what should be a close game. However, I’m being a bit of a coward and grabbing an extra point with some more juice. I don’t want to lose if this ends up being decided by a touchdown.
Bet: Texas +7.5 (-143 – 1.5 units) & Texas ML (+200 – 0.5 units)
Added Plays
PARLAY: Central Michigan Alt +7.5 vs. Buffalo & Toledo ML vs. Miami Ohio (-123 – 1.5 units)
Troy-Old Dominion Under 52.5 (-109)
Clemson ML (+108 – 1.5 units) vs. Louisville
UCLA-Ohio State Under 48.5 (-110)
PARLAY: USC ML vs. Iowa & Missouri ML vs. Mississippi State (-109 – 1.5 units)
Arizona State -10.5 (-112) vs. West Virginia – I gave this out Monday night on Cashing Out!
Baylor +8.5 (-110 – 1.5 units & Baylor ML (+250 – 0.5 units) vs. Utah – I gave this out Monday night on Cashing Out!
Check the Pro Picks page for any additional plays, or come back here right before kick-off to see if I added something on the game you’re interested in.
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2025 Record: 54-54 (-1.83 units)
