Week 6 of the 2025 college football season is here and our VSiN team is attacking it relentlessly. If you haven’t already, make sure you check out the Week 6 CFB Betting Hub for write-ups and picks from all of our talented analysts. However, I’d love for you to keep reading for my college football best bets and predictions for this exciting Week 6 slate. I’ll probably add some picks as lines move and more information comes out later in the week — and on game day. If I do, I’ll put them on the VSiN Pro Picks page. Don’t miss out on those.
MORE: Check out our Pro Picks page for college football best bets from all of our analysts
Wisconsin Badgers at Michigan Wolverines – 12:00 pm ET
Backing Wisconsin won’t be fun. The Badgers are currently tied for 68th in the nation in Adjusted EPA per play (-0.04), and scoring has been very difficult for them. That’s not a great thing heading into a meeting with a Wolverines defense that is 20th in the nation in Adjusted EPA per play allowed (-0.20).
This is, however, a game with a total of only 43. That makes Wisconsin +17.5 very intriguing. It’s hard to cover big numbers in low-scoring games, meaning Michigan would have to play a near-perfect game in order to do so. I’m not sure I see that happening. Since Luke Fickell arrived in Madison, his team is 3-2 both straight-up and against the spread in road games with totals between 42.5 and 49.
For as bad as things have been for the Badgers, they are currently tied for 11th in the nation in Rush EPA per play allowed (-0.19). They should be able to limit the damage the Wolverines do on the ground, putting all kinds of pressure on Bryce Underwood to make plays with his arm. And while Wisconsin has had trouble defending the pass this year, this isn’t a matchup with Ty Simpson. The Badgers secondary should be able to hold up, especially coming off a bye.
The only real question is: Can Wisconsin score enough points to keep this game somewhat close? While it might seem unlikely, it should help that offensive coordinator Jeff Grimes had two weeks to prepare for the Michigan defense. And not only that, but Danny O’Neil has had some significant time to work with the first-team offense in practice. That should be big after a few weeks of Billy Edwards’ injuries messing with things.
Bet: Wisconsin +17.5 (-110)
Boise State Broncos at Notre Dame Fighting Irish – 3:30 pm ET
I wouldn’t say I’m blindly taking Notre Dame Overs right now, but I’m pretty damn close to blindly taking Notre Dame Overs right now. The Irish come into this game after having gone Over in four consecutive games, and they’re averaging 56.0 points per game over the last two weeks. This Notre Dame offense is suddenly looking extremely potent, and the team is pairing that offense with a defense that is 98th in the nation in Dropback EPA per play allowed (0.14).
There’s just no reason to believe that this Irish secondary can keep the Broncos passing game down. After a bad game against South Florida to start the year, Boise is averaging 49.0 points per game over the last three weeks. Maddux Madsen is also throwing the ball very well, as he’s up at 1,129 passing yards with nine touchdowns and only one pick.
It’s just hard to imagine either defense really playing well in this one. So, while 62.5 might seem like a high number, there’s a chance it isn’t close to high enough.
Bet: Over 62.5 (-110 – 1.5 units)
Texas Tech Red Raiders at Houston Cougars – 7:00 pm ET
Our analytics expert Steve Makinen has an estimated line of Texas Tech -13.8 in this game, and I’m similarly struggling to understand how the Red Raiders are only laying 11. Last week, Houston needed overtime to beat a very bad Oregon State team. The Cougars are also just 54th in the nation in Adjusted EPA per play (+0.06); the Red Raiders are 12th (+0.27).
Texas Tech is also coming off a road beatdown of a very good Utah team, as the Red Raiders won that one 34-10 at Rice-Eccles Stadium. So far, this team looks absolutely tremendous on both sides of the ball, but the defensive line has been something else. That unit up front should eat against a Houston O-Line that isn’t anything special. And I’m not sure we’ll see Conner Weigman shred this talented secondary with his arm. On the other side of the ball, Texas Tech’s running game should be pretty dominant, and that should be enough for the Red Raiders to win by at least two scores.
This is also a Texas Tech team that is coming off a bye week. So, this is a well-rested group going against a team that was in a war last week. And the Red Raiders are 5-2 ATS off a bye week under Joey McGuire.
Bet: Texas Tech -11 (-110)
Added Plays
PARLAY: New Mexico Alt +10.5 vs. San Jose State & Colorado State Alt +10.5 vs. San Diego State (-119 – 1.5 units)
PARLAY: Cincinnati Alt +8.5 vs. Iowa State & Pittsburgh ML vs. Boston College (-115 – 1.5 units)
Wyoming +4.5 (-110 – 1.5 units) & Wyoming ML (+170 – 0.5 units) vs. UNLV
Kansas vs. UCF Over 51.5 (-123)
Florida State +4.5 (-105 – 1.5 units) & Florida State ML (+165 – 0.5 units) vs. Miami – CLICK HERE for my Miami-FSU preview!
Alabama -10 (-113) vs. Vanderbilt – CLICK HERE for my Vanderbilt-Alabama preview!
Duke ML (-160 – 1.5 units) vs. California
Check the Pro Picks page for any additional plays, or come back here right before kick-off to see if I added something on the game you’re interested in.
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2025 Record: 24-25 (-1.92 units)
