Nine college football games are left in the month of October and that is not a trick. It may not really be a treat either, as we’re on the backside of the 2025 college football season, though that also means the games are getting more important and we’ll have our first CFP rankings in Week 11. For now, though, it’s all about Week 10 college football and the games that we have on the horizon.
I cautioned readers last week about the weather. While we didn’t have many games last week where Mother Nature was a factor, they’re coming. I’m not saying you need to bet scared on Sunday, Monday, or Tuesday, but I am saying that as the market matures and these lines settle in, you’ll want to at least take a peek at what could be in the forecast.
Without further ado, let’s look at the early Week 10 college football odds, initial line movements, and some of this week’s big games.
Check out the DraftKings College Football Betting Splits and Circa College Football Betting Splits to follow line moves all week long!
Week 10 College Football Odds Report
Lines as of Sunday, October 26 at 5:15 p.m. PT
UTEP at Kennesaw State (-9.5, 51)
Tuesday, 7 p.m. ET
We all better savor the Tuesday and Wednesday Conference USA action because it goes away after this week. On the plus side, we do get MACtion to continue our run of 49 straight days with a football game. Most shops in the market opened Kennesaw State -10 or higher in this one, but some initial money hit the board on UTEP, as the Miners are coming off of a bye. This is also a case where box score study is important, as Kennesaw State crushed FIU 45-26 last week, but the Panthers did have over 500 yards of offense while leaving points on the field.
FIU at Missouri State (-4, 51.5)
Wednesday, 8 p.m. ET
While most of the market was sitting 3.5 as of Sunday afternoon, Circa was showing a -4, as the initial indications here are that Missouri State with a healthy-ish Jacob Clark at QB is the side in this game. We’ve also seen the total get knocked up a tad. DraftKings had this one -2.5 at open and bettors scrambled to get it shy of the key number. This is not a game that will draw volume, even as one of just two games on Wednesday because we have a World Series game and NBA, but blowing through and staying over a key number is a fairly noteworthy development.
Tulane (-3.5, 55.5) at UTSA
Thursday, 7:30 p.m. ET
Keep a very close eye on this line. I think this game has the chance to set up as something of a “sharp vs. square” type of game, in that the volume of money and bets is on Tulane, but the more respected bettors are on UTSA. The Roadrunners have been disappointing this season to say the least, but Tulane has had a lot of close wins this season. Both teams are on extra rest, having played on Saturday of Week 8. It seems like the initial interest was on UTSA, so we’ll see if that continues, as Circa opened -5 and sat -3.5 with the rest of the market.
North Carolina at Syracuse (-2, 46.5)
Friday, 7:30 p.m. ET
It’s been a rough season for the Tar Heels and the last two weeks have been excruciating, as they had chances to beat both Cal and Virginia, but made critical errors at the end of the game. They fell an inch short against Virginia while going for two. They fumbled in the end zone for the go-ahead score against Cal. Program GM Michael Lombardi has been raked over the coals again and again in the media. So, there aren’t a lot of positive vibes in Chapel Hill, but the team is still fighting. Syracuse, meanwhile, hasn’t played a competitive game in the ACC since last month. DraftKings popped this line on the board at PK and money hit Syracuse, but this is in a precarious spot to the point where I think North Carolina could be a road favorite by kickoff.
North Carolina-Syracuse Matchup
Vanderbilt at Texas (-2.5, 45.5)
Saturday, Noon ET
The status of Arch Manning will dictate where this line goes, as he reportedly suffered a concussion late in the game against Mississippi State. The Vanderbilt love is a big story in college football right now, but Diego Pavia has really not had good stats the last few weeks throwing the football. The betting market has really dug in on certain defensive teams this season and Texas is one of them, as they seem to be continuously favored in games that look a little bit precarious. I am very interested to see where this line goes if it’s Manning or Matthew Caldwell. I honestly feel like Texas is the right side either way.
Georgia (-7.5, 50.5) vs. Florida
Saturday, 3:30 p.m. ET
Cocktails, anyone? The World’s Largest Outdoor Cocktail Party has a different look this year, as WR coach Billy Gonzales has taken over for Billy Napier. Trading out one Billy for another probably won’t solve all of Florida’s issues, but Napier was booed off the field following the win over Mississippi State, so this was a long time coming. So far, modest action on Florida has come in, as Circa opened -8 and DraftKings got down to -7 early before settling back in line with the market.
Delaware at Liberty (-3, 51)
Saturday, 3:30 p.m. ET
The Flames have not been as bright as we all expected this season, but they were the side taking the initial money on this game. Circa opened Liberty -2. DraftKings and Fanduel both opened -2.5 on Liberty and got bet up quickly. Fanduel went all the way to 4.5 before Delaware buyback hit the board. Delaware is a tough team to figure out this season because they’ve had some nice yardage totals and some good passing performances, but their defense hasn’t been up to par. For Liberty, they just play down to the level of their opponents too much. Remember, with games like this on a jam-packed Saturday, none of this is public money. It’s all going to be sharper in nature, which is an important distinction when evaluating line moves.
Virginia (-4, 54.5) at Cal
Saturday, 3:45 p.m. ET
There are a couple of lines per week where Fanduel hangs a bad number and gets called out on it. Seemingly this was one of them, as the nation’s market share leader put up Cal +6.5 and now the number sits 3.5 or 4 market-wide. We have seen a lot of geographically-based line moves this season and last season with the expanded conferences and the fact that Cavaliers, off of a game that they won by an inch, have to travel out to Berkeley seemed to be ammunition enough for early bettors to hop on the Golden Bears. Now we wait to see if this is the stopping point or if more Cal cash comes in.
Oklahoma at Tennessee (-3.5, 55)
Saturday, 7:30 p.m. ET
This is a line that I am watching closely. I was on Ole Miss last week, citing the fact that Oklahoma’s defense had not played that good of an offense yet. As it turns out, that handicap was correct and the Rebels mostly coasted to a win. John Mateer also looked bad again for the Sooners. But those defensive metrics were strong in OU’s favor and they were a sharper side in nature last week. Will that be the case again this week? I think the early indications are yes, as we’ve seen some grabbing the defensive dog getting points. I think we see the public pile in on Tennessee after Oklahoma’s recent defeats. I also think some sharper bettors will take the Vols, too. I think this line goes up rather than comes down.
Wake Forest at Florida State (-8, 52)
Saturday, 7:30 p.m. ET
It seems we’ve finally reached the point of paying a premium on Wake Forest. DraftKings had Florida State -7 here and the market was north of the key number across the board on Sunday afternoon. This feels like a “last stand” sort of spot where bettors want to back the more talented Seminoles, but this may be the last chance that they get. Florida State is off of a bye. Mike Norvell is off of a vote of confidence from the school. Clemson is on deck. I know I wouldn’t be excited about laying over a touchdown, even with the Demon Deacons off of a very emotional win, but some people do seem excited about it. Circa opened -7 here.
Wake Forest-Florida State Matchup
Keep an eye out for more line movements by tracking our VSiN College Football Betting Splits.
