Before we get too deep into the 2025 season and we miss a lot of opportunities, I figured it would be prudent to share the top head-to-head series data available for bettors on the MLB schedule. All of these trends have produced an ROI of at least 46% and a minimum of 8 units of profit over the last three seasons for those that have backed them consistently. Of course, how teams fare against other specific teams is just one small piece of the puzzle. I like to think that the VSiN MLB Analytics Reports put together all of the pieces of that puzzle, so if you haven’t tried them, I highly encourage you to. These head-to-head nuggets are just one of the many valuable pieces you’ll find on a daily basis for MLB. 

You will see that a few of these series have already played in 2025. Hopefully, you saw our analytics reports for earlier this week, where it was pointed out how well road teams and underdogs tend to fare in the Toronto-Boston series. The Blue Jays wound up taking three of four games in Boston from Monday through Thursday, for a profit of +3.15 units. Clearly, that series is on pace to continue its pattern in 2025. If the rest do as well, those of us who bookmark the trend qualifying dates below should be far better off in our baseball bankrolls because of it. 

 

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Note: Data used in this study dates back to the beginning of the 2022 MLB season, and includes games through Thursday, April 10th. The trends are listed in order of the next applicable date for that matchup.

MLB head-to-head series trend #1
Home teams are on a 15-2 (88.2%) run in the Giants-Phillies National League series. This has netted +13.27 units for an ROI of 78.1%.
This is our first trend to test the rest of the way, as San Francisco visits Philadelphia for four games 4/14-4/17. They won’t meet again until 7/7-7/9 in San Francisco.

MLB head-to-head series trend #2
FAVORITES are on a 22-3 (88%) run in the White Sox-Twins AL Central rivalry. This has netted +16.46 units for an ROI of 65.8%. 
After having already played a three-game set in early April, the White Sox visit the Twins for the second of four seasons series from 4/22-4/24. The teams don’t meet again until 8/22-8/24 in Chicago and then again for a four-game set in Minnesota 9/1-9/4.

MLB head-to-head series trend #3
CLEVELAND has dominated Minnesota in recent seasons of head-to-head play, going 27-10 (73%) for +19.83 units for an ROI of 53.6%. 
The Guardians and Twins meet for four series in 2025. The first is a four-game set in Cleveland 4/28-5/1. The next is in Minnesota 5/19-5/21, then back in Cleveland 8/1-8/3, and finally in the Twin Cities again 9/19-9/21.

MLB head-to-head series trend #4
Over the total is on a 21-7 run in the Pirates-Cubs head-to-head series since September 2022. This has netted +13.15 units for an ROI of 47%.
The Pirates and Cubs meet for four series in 2025. The first and last are in Pittsburgh, 4/29-5/1 and 9/15-9/17. In between, they’ll play in Chicago, four games from 6/12-6/15 and three more 8/15-8/17.

MLB head-to-head series trend #5
Underdogs are on a 22-9 (71%) run in the Toronto-Boston AL East rivalry. This has netted +20.28 units for an ROI of 65.4%. 
After concluding a four-game set this past Thursday, the Red Sox visit the Blue Jays for the second of four seasons series from 4/29-5/1. The teams will also meet in Boston 6/27-6/29 and again in Toronto 9/23-9/25.

MLB head-to-head series trend #6
SAN FRANCISCO is on a 19-3 (86.4%) surge hosting Colorado, netting +12 units for an ROI of 54.5%.
The Rockies visit San Francisco for four games from 5/1-5/4 and then again to close the regular season 5/26-5/28.

MLB head-to-head series trend #7
KANSAS CITY is on a run of 13-1 (92.9%) versus the Chicago White Sox, netting +11.95 units for an ROI of 85.4%. 
The Royals host the White Sox for a four-game set from 5/5-5/8, then visit Chicago 7/6-7/8. They also host them 8/15-8/17 and return to Chicago again on 8/25-8/27.

MLB head-to-head series trend #8
BALTIMORE has won its last 10 (100%) games versus Minnesota, netting +11.7 units for an ROI of 117%. 
The Orioles visit the Twins from 5/6-5/8, then host them a week later from 5/13-5/15.

MLB head-to-head series trend #9
Favorites are on a 16-1 (94.1%) surge in the head-to-head series between the Mets and Pirates. This has netted +23.05 units for an ROI of 53.6%.
The first New York-Pittsburgh series is set for 5/16-5/18 in the Big Apple. The teams then square off in Pittsburgh on 6/27-6/29.

MLB head-to-head series trend #10
Road teams are on a 29-14 (67.4%) surge in the in-state AL West rivalry between Houston and Texas. This has netted +23.05 units for an ROI of 53.6%. 
The Rangers & Astros meet for four series in 2025. The first is a four-game set in Arlington on 5/15-5/18. The next is in Houston on 7/11-7/13, then back in Arlington on 9/5-9/7, and finally a return to Houston on 9/15-9/17.

MLB head-to-head series trend #11
TEXAS has built an 11-game (100%) winning streak versus the Chicago White Sox. This has netted +11.1 units for an ROI of 100.9%.
The Rangers and White Sox meet twice in 2025, the first from 5/23-5/25 in Chicago, and then on 6-13/6/15 in Arlington.

MLB head-to-head series trend #12
Home teams in the Kansas City-Minnesota AL Central rivalry are on a 32-10 (76.2%) run in head-to-head play. This has netted +22.02 units for an ROI of 52.4%. 
Host Kansas City took three of four games from Minnesota this week. The next matchup is in Minnesota on 5/23-5/25 and then again 8/8-8/10. The teams finally square off again in KC on 9/5-9/7.

MLB head-to-head series trend #13
MILWAUKEE is on an extended 27-9 (75%) run versus Cincinnati in head-to-head play. This has netted +16.79 units for an ROI of 46.6%.
After taking three of four games last week, the Brewers next face the Reds on the road on 6/2-6/4. They return to Cincinnati on 8/15-8/17, and finally host a season-finale series on 9/26-9/28.

MLB head-to-head series trend #14
Favorites are on a 16-2 (88.9%) surge in the Athletics-Minnesota head-to-head series. This has netted +11.95 units for an ROI of 66.4%.
The Athletics and Twins meet twice in 2025, the first a four-game series from 6/2-6/5 in Sacramento, and then 8-19-8/21 in Minnesota.

MLB head-to-head series trend #15
TEXAS is on a very profitable 13-1 (92.9%) run versus Tampa Bay. This has netted +13.28 units for an ROI of 94.9%.
After sweeping the Rays at home last weekend, the Rangers will visit Tampa Bay for a three-game set on 6/3-6/5.

MLB head-to-head series trend #16
CLEVELAND is on a 17-3 (85%) run versus the Athletics dating back to April 2022. This has netted +13.25 units for an ROI of 66.3%. 
The Guardians and Athletics meet twice in 2025, the first series from 6/20-6/22 in Sacramento, and then 7/18-7/20 in Cleveland.

MLB head-to-head series trend #17
The last nine games (100%) of the Houston-Philadelphia head-to-head series went Under the total. This has netted +9 units for an ROI of 100%.
The Astros and Phillies play one three-game set in 2025, in Houston, 6/24-/6/26.

MLB head-to-head series trend #18
DETROIT has won its last 10 (100%) games when visiting the Chicago White Sox. This has netted +10 units for an ROI of 100%. 
The Tigers visit Chicago for four games from 7/2-7/5 and then again from 8/11-8/13.

MLB head-to-head series trend #19
The YANKEES are on a 9-1 (90%) run versus Houston. This has netted +10.07 units for an ROI of 100.7%.
The Yankees host the Astros from 8/8-8/10 and then visit Houston from 9/2-9/4.

MLB head-to-head series trend #20
Home teams have swept the last eight (100%) games in the interleague series between the Rangers and Phillies. This has netted +8.25 units for an ROI of 103.1%. 
The Rangers host the Phillies for the teams’ one and only series in 2025, 8/8-8/10.

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