The long awaited return of MLB is finally here. Let’s examine where smart money is leaning for tonight’s standalone Opening Day matchup between the New York Yankees and San Francisco Giants using our VSiN MLB Betting Splits, which are updated every 5 minutes and come directly from DraftKings and Circa Sports.
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8:05 p.m. ET: New York Yankees (-125, 7) at San Francisco Giants
The Yankees went 94-68 in 2025, reaching the postseason and advancing to the ALDS where they fell to the Blue Jays in five games. On the other hand, the Giants finished 81-81 last year and failed to make the playoffs.
The Yankees win total for 2026 is 90.5 at DraftKings with both sides showing even juice at -110. Meanwhile, the Giants win total sits at 80.5 this season with both sides also juiced at -110.
In tonight’s season opener, the Yankees send out lefty Max Fried (19-5, 2.86 ERA in 2025) and the Giants counter with righty Logan Webb (15-11, 3.22 ERA).
This line opened with New York listed as a -115 road favorite and San Francisco a +100 home dog.
Sharps have jumped on the Bronx Bombers laying short chalk, driving the Yankees up from -115 to -125.
At DraftKings, the Yankees are taking in 77% of moneyline bets and 72% of moneyline dollars, a one-way Pro and Joe bet split in favor of New York earning a straight up victory.
New York has betting system value as an Interleague favorite, with the lack of familiarity benefiting the better team who is expected to win. The Yankees are also a correlative betting “favorite low total” (7) system play, with the fewer amount of expected runs scored more likely to come from the better team as well.
Favorites have traditionally done well on Opening Day, with chalk going 193-115 (63%) with a 6% ROI since 2005.
New York went 22-10 (69%) with a 4% ROI with Fried on the mound last season. On the flip side, San Francisco went 18-16 (53%) with a -9% ROI when Webb took the bump in 2025. The Giants also went just 17-25 (41%) with a -24% ROI against lefties last year.
In terms of the total, we’ve seen it remain relatively steady at 7 from open to current.
At DraftKings, the over is taking in 51% of bets and 52% of dollars. However, a few books are juicing up the under 7 (-115) slightly.
The forecast calls for mid to low 60s with 10-15 MPH winds blowing out to dead center.
Oracle Park has historically been one of the more profitable under ballparks in MLB, with unders going 137-101 (58%) with a 10% ROI in Giants home games since 2023.
