The 2025 NFL schedule was officially released on Wednesday, May 14th. We now know exactly what we’re looking at for the upcoming season, so you can expect our NFL betting coverage to ramp up significantly. We’re going to have a ton of written content as the season gets closer and closer, and that includes our VSiN 2025 NFL Betting Guide — which is coming early this summer. We’re also going to be talking NFL regularly on our live VSiN programming. Below, you’re going to find all of the Thursday Night Football games for the 2025 NFL season, which officially kicks off with the Dallas Cowboys taking on the defending Super Bowl champion Philadelphia Eagles.
Week 1: Dallas Cowboys at Philadelphia Eagles (-7, 46.5) – NBC
The Eagles begin their Super Bowl defense with a divisional game against the Cowboys. Philadelphia is 5-1 both straight-up and against the spread in its last six home games against Dallas. Last year, the Eagles absolutely hammered the Cowboys, winning 41-7 as 7.5-point favorites on December 29th.
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Week 2: Washington Commanders at Green Bay Packers (-1.5, 48.5) – Prime Video
Two of the league’s most exciting young quarterbacks — Jordan Love and Jayden Daniels — clash at Lambeau Field, where the Packers were 6-3 SU and 5-4 ATS in 2024. But the Commanders are hoping to take things a step further in 2025, and winning in Green Bay can send a message to the rest of the NFC.
Week 3: Miami Dolphins at Buffalo Bills (-8.5, 48.5) – Prime Video
In a big divisional showdown, the Dolphins will be looking to win in Orchard Park for the first time since 2016. However, Miami has covered in three of its last four trips to Buffalo, and Tua Tagovailoa shouldn’t have to deal with freezing cold temperatures this early in the season. That’s good news for the Dolphins, their fans and whoever else is sick of hearing statistics about how the lefty performs in blizzard-like conditions.
Week 4: Seattle Seahawks at Arizona Cardinals (-2.5, 46.5) – Prime Video
The Seahawks have enjoyed this matchup over the years. Seattle is on a seven-game winning streak against Arizona, and the team covered in six of those games. The Seahawks even won by 10 in their trip to the desert last season. Will that continue with Sam Darnold now running the show for Seattle?
Week 5: San Francisco 49ers at Los Angeles Rams (-1.5, 47.5) – Prime Video
San Francisco used to have Los Angeles’ number, but that has changed recently. The Rams have won three in a row against the 49ers, and they have also covered in four straight. It’ll now be interesting to see how this Thursday Night Football showdown goes. San Francisco is expecting to bounce back from a down year in 2024, but Los Angeles continues to improve its roster.
Week 6: Philadelphia Eagles (-7, 43.5) at New York Giants – Prime Video
If the Giants are going to go Over their win total of 5.5, they’re going to need a home win or two against an unlikely opponent. But can they beat the Eagles? Philadelphia won 28-3 at MetLife Stadium last year, and the team is now 7-2 SU and 5-3 ATS in its last eight games against New York. But the Giants have significantly upgraded their quarterback room, so perhaps they’re ready to start competing with NFC East rivals.
Week 7: Pittsburgh Steelers at Cincinnati Bengals (-4.5, 46.5) – Prime Video
Cincinnati was just 3-5 both SU and ATS in home games last year. One of those losses came at the hands of Pittsburgh, which won 44-38 in a shootout on December 1st. The Steelers have now won-and-covered in three straight road games against the Bengals, and Cincinnati will surely be looking to change that in this primetime game.
Week 8: Minnesota Vikings at Los Angeles Chargers (-3, 44.5) – Prime Video
The Chargers went 5-3 both SU and ATS in home games last season, and they should continue to get better as they get deeper into Jim Harbaugh’s tenure. However, this is going to be a fascinating game to watch. Minnesota is the better defensive team, and the offense has more talent than Los Angeles’ offense. But how will JJ McCarthy do as the Vikings starter? Can he out-duel Justin Herbert?
Week 9: Baltimore Ravens (-5.5, 47.5) at Miami Dolphins – Prime Video
Lamar Jackson loves himself a night game, and this could be a fascinating one. Dolphins defensive coordinator Anthony Weaver was an assistant head coach and defensive line coach for the Ravens. Will he have a plan in place to slow down the Baltimore offense? Or will Ravens offensive coordinator Todd Monken know how to torch Weaver’s defense?
Week 10: Las Vegas Raiders at Denver Broncos (-6.5, 43.5) – Prime Video
The Broncos demolished the Raiders twice last year, winning 34-18 when the two met in Denver on October 6th and then winning 29-19 in Vegas on November 24th. The Raiders should be better with Pete Carroll on the sidelines and Geno Smith under center, but how big of a difference will that make? The Broncos should only get better as Bo Nix spends more time in Sean Payton’s offense, and Denver was 6-2 both SU and ATS at home last season.
Week 11: New York Jets at New England Patriots (-5.5, 42.5) – Prime Video
The Jets snapped a 12-game road losing streak against the Patriots with a win on January 7th, 2024, but New England got back in the win column at Gillette Stadium with a 25-22 home win over New York last year. This year’s game should be a fun one, as we don’t know much about either team. The Jets are hoping Justin Fields gives their offense a jolt, and the Pats are banking on Mike Vrabel to help the team return to glory.
Week 12: Buffalo Bills (-3.5, 46.5) at Houston Texans – Prime Video
Last year, the Texans earned a 23-20 win as 1-point home favorites against the Bills, as Ka’imi Fairbairn kicked a 59-yard field goal as time expired. This year, Buffalo will be hoping to get some revenge inside NRG Stadium. Josh Allen was just 9 for 30 when these teams met in 2024, and he’s surely capable of spinning it better than that. But Houston is also hoping to enter the AFC’s top tier, making this a must-watch game.
Week 13: Chicago Bears at Philadelphia Eagles (-7, 46.5) (Black Friday) – Prime Video
This is one of the most exciting games of the year. How will Ben Johnson and a retooled Bears team do against the defending Super Bowl champions? Caleb Williams is expected to make big strides in Johnson’s offense, but can he help his offense keep up with Jalen Hurts and Co.? And how will the new-look Bears line look against Vic Fangio’s scary defensive front?
Week 14: Dallas Cowboys at Detroit Lions (-6, 48.5) – Prime Video
The Cowboys will be looking for revenge when they head to the Motor City, as they lost by 38 points when they hosted the Lions last season. But Detroit is still the more talented team, and it’s hard to believe in Dallas turning the tables strictly because Johnson left the Lions for the Bears. Are we looking at another blowout win for Detroit in this matchup? For what it’s worth, Dallas had won six straight in this head-to-head series before last year’s whooping.
Week 15: Atlanta Falcons at Tampa Bay Buccaneers (-5.5, 47.5) – Prime Video
The Falcons are looking to snap the Buccaneers’ four-year streak of winning the NFC South, and it’ll be interesting to see if this game has divisional consequences come Week 15. Either way, it will be fun to see how Michael Penix Jr. does as Atlanta tries to keep up with Baker Mayfield and a high-powered Tampa offense. For as good as the Bucs have been in recent years, the Falcons are 4-1 SU in their last five meetings with the Bucs. They have also covered in five of their last six games.
Week 16: Los Angeles Rams (-1.5, 44.5) at Seattle Seahawks – Prime Video
Last season, the Rams covered in both of their meetings with the Seahawks, and they even won 26-20 in overtime when the teams met at Lumen Field on November 3rd, 2024. Los Angeles has now covered in eight of its last nine games against Seattle, and the team has also won six of those nine outright. But the Seahawks are banking on some big-time improvement in Year 2 of Mike Macdonald, even though they did make some interesting swaps on offense. One of those moves was bringing in Cooper Kupp, who will get a crack at his former team here.
Week 17: Denver Broncos at Kansas City Chiefs (-4.5, 44.5) (Christmas) – Prime Video
The most recent meeting between these teams saw the Broncos earn a 38-0 win in Denver, but that was the final game of the regular season. Kansas City was resting its starters, which meant Carson Wentz was under center. However, the Broncos nearly beat the Chiefs in their other meeting last season, as they lost 16-14 at Arrowhead Stadium in a game in which their game-winning field goal attempt was blocked. Let’s see what happens this year. Denver is only getting better while Kansas City is getting older. The Broncos are hoping to take over this division soon.
