49ers odds shift as Jimmy Garoppolo out for season with broken foot


2022 Mr. Irrelevant Brock Purdy now the 49ers starting QB

Mr. Irrelevant has suddenly become extremely relevant, as Brock Purdy is now the starting quarterback for one of the top teams in the NFC. The San Francisco 49ers were +650 at DraftKings Sportsbook shortly after the Garoppolo announcement hit the newswire and moved to +700 and then +900 fairly quickly. At the time of Garoppolo’s injury, only the Philadelphia Eagles had lower odds among NFC teams and only the Buffalo Bills and Kansas City Chiefs had lower odds among AFC teams.

Purdy was 25-of-37 for 210 yards with a couple touchdowns and an interception in relief of Garoppolo, who was injured on San Francisco’s first offensive possession of the game. The 49ers won 33-17 with a strong defensive performance after giving up a 75-yard TD pass on the first play.


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Now the 49ers will have to rally around Purdy, as Trey Lance continues to rehab from the long-term injury he suffered in Week 1 against the Bears.

Super Bowl LVII Odds

Buffalo Bills +400
Kansas City Chiefs +500
Philadelphia Eagles +500
Dallas Cowboys +750
San Francisco 49ers +900
Cincinnati Bengals +1600
Baltimore Ravens +1800
Miami Dolphins +2000
Minnesota Vikings +2000
Tampa Bay Buccaneers +2500
All others +4000 or higher

Purdy looked good in relief, but he represents a significant downgrade from Garoppolo and teams will be able to plan for him now. The 49ers have the NFL’s best defense by a lot of metrics, but the offense will take a hit. How big that hit will be remains to be seen, but the 49ers were -5.5 on the lookahead line against the Buccaneers and we are sure to see a huge adjustment unless the Buccaneers have major injuries on Monday Night Football against the Saints.

San Francisco 49ers schedule

Week 14: vs. Tampa Bay Buccaneers
Week 15: at Seattle Seahawks (Thursday)
Week 16: vs. Washington Commanders
Week 17: at Las Vegas Raiders
Week 18: vs. Arizona Cardinals

NFC Playoff Picture

The 49ers are 8-4 and hold a one-game lead in the NFC West over the Seahawks, so both the division and a playoff spot are far from certainties. The 49ers are a half-game ahead of the first wild card Cowboys with Sunday Night Football pending. They are a half-game ahead of the Giants, who tied in Week 13 and are 7-4-1. The Seahawks are 7-5 and the Commanders are 7-5-1.

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See the latest NFL odds, Super Bowl odds and NFL betting splits.