In the second of the two Week 4 Monday Night Football matchups in the 2025 NFL season, the Denver Broncos host the Cincinnati Bengals at Empower Field at Mile High. We’ll be diving into all of the primetime games this season, and this one isn’t any different. With that in mind, keep reading for betting odds, picks and player props for this exciting showdown. Also, make sure you head over to our Week 4 NFL Betting Hub for a look at all of our NFL betting content.
MORE: Head to the Pro Picks page for best bets from all of our VSiN hosts and analysts!
How To Watch Bengals vs. Broncos
When: Monday, September 29th at 8:15 pm ET
Where: Empower Field at Mile High in Denver, Colorado
Channel: ABC
Bengals vs. Broncos Odds
Odds from DraftKings Sportsbook as of Sunday, September 28th. Look around for the best prices!
Moneyline: Broncos -520, Bengals +390
Spread: Broncos -7.5 (-110), Bengals +7.5 (-110)
Total: Over 44.5 (-105), Under 44.5 (-115)
RELATED: Check out our Bengals vs. Broncos matchup page!
Bengals vs. Broncos Analysis
The Bengals got absolutely demolished by the Vikings last week, losing 48-10 in a game in which Jake Browning threw for only 140 yards with two interceptions. Cincinnati also lost three fumbles in the game, looking completely inept as an offensive unit. Now, people are running to back the Broncos, with our VSiN betting splits page showing serious action on Denver.
Personally, I’d caution against putting too much weight in one week. Browning might have been a disaster in Minnesota, but he was able to get his team over the finish line against Jacksonville one week earlier. Also, Browning was a solid starter when forced into action in 2023, throwing for 1,936 yards with 12 touchdowns in parts of nine games. The Bengals are also led by a sharp offensive coach in Zac Taylor, and they had some extra time to get ready for this game. And this isn’t the same Broncos passing defense we saw last year. Denver has been beatable through three weeks, so there should be some throws to be made for Browning.
With all of that in mind, I’m not sure I’d be running to lay 7.5 to 8.5 points with Denver. Instead, I’d simply jump on the Over in this one. There’s a 43.5 out there at one prominent sportsbook, and I wouldn’t mind going Over 44 or 44.5 either.
It’s just hard not to like the Broncos to rip through this miserable Bengals defense. Cincinnati is 20th in the NFL in EPA per play allowed (0.046), and the group has struggled equally against the run and the pass. That’s not what you want against a Sean Payton offense. Denver is going to have no problem getting J.K. Dobbins and RJ Harvey going on the ground, and that’ll then open up the play-action playbook for Payton to attack with Bo Nix. The second-year signal caller hasn’t looked great this season, but he should look pretty damn good against this secondary. And he’s highly efficient when working off a strong running game.
If Denver just performs as expected against this lousy defense, Cincinnati would just need to chip in a little in order for this one to reach the 45-point mark. And for what it’s worth, these teams combined for 48 before heading to overtime in last year’s late-season matchup, which had real stakes. Sure, Joe Burrow was out there for the Bengals in that one, which definitely helped a ton. But this game won’t have the same playoff feel, meaning it should be less physical. And Denver’s defense has gotten worse, which could give Cincinnati a shot at scoring multiple touchdowns.
Since Taylor took over as the Bengals head coach, the Over is also 11-7 when the team is coming off a game in which it scored 14 or fewer points. And under Payton, the Over is 11-7 when the Broncos are favorites.
Bengals vs. Broncos Player Props
Bo Nix Over 1.5 Passing Touchdowns (+100)
While Nix hasn’t looked good to start this season, it’s hard to imagine him struggling forever. Last year, he finished the season with at least two touchdowns in seven of his final eight regular-season games, with one of them being a three-touchdown performance against this Bengals defense. Realistically, Denver has gotten better around him, too.
Nix was also awesome at home last year, throwing for 2,004 yards with 19 touchdowns and a Passer Rating of 102.0. Well, returning home after back-to-back road games could get the talented young quarterback back on track.
Bengals vs. Broncos Pick
I feel sick in the head expecting a shootout in a Browning game, but I can see this being a high-scoring affair. Denver should carve up the Cincinnati defense, and the Bengals should bounce back after last week’s poor performance. This number is also rather low, so we don’t even need a true shootout for this one to come through. I’m also going to play Nix to throw for 2+ TDs.
Pick: Over 43.5 (-118 – 1.5 units) & Nix Over 1.5 Passing TDs (+100)
