On September 25th, the Arizona Cardinals host the Seattle Seahawks at State Farm Stadium for the 2025 NFL season’s Week 4 Thursday Night Football matchup. We’ll be diving into all of the primetime games this season, and this one isn’t any different. With that in mind, keep reading for betting odds, picks and player props for this exciting showdown. Also, make sure you head over to our Week 4 NFL Betting Hub for a look at all of our NFL betting content.
MORE: Head to the Pro Picks page for best bets from all of our VSiN hosts and analysts!
How To Watch Seahawks vs. Cardinals
When: Thursday, September 25th at 8:15 pm ET
Where: State Farm Stadium in Glendale, Arizona
Channel: Prime Video (Amazon)
Seahawks vs. Cardinals Odds
Odds from DraftKings Sportsbook as of Tuesday, September 23rd. Look around for the best prices!
Moneyline: Seahawks -122, Cardinals +102
Spread: Seahawks -1.5 (-108), Cardinals +1.5 (-112)
Total: Over 43.5 (-105), Under 43.5 (-115)
Seahawks vs. Cardinals Analysis
Our VSiN matchup pages are packed with valuable information, so I’d suggest checking them out when you’re torn on certain games. Well, when scanning through this week’s slate, it immediately jumped out that Steve Makinen had an estimated line of Seattle -5.1 in this one. That suggests there’s a pretty significant edge in backing the Seahawks at their current prices. For me, that was especially nice to see, as I already had a strong lean on Seattle.
This Seahawks team has been awesome on the road under Mike Macdonald. Since he took over, Seattle is 8-1 straight-up and 5-3 against the spread when playing away from home. In that time, the Seahawks are also 5-1 both SU and ATS when playing as road underdogs of 7 or fewer. Meanwhile, under Jonathan Gannon, the Cardinals haven’t been great when games are expected to be tight. Since he took over, Arizona is just 5-7 SU in games with lines of +3 to -3. The Cardinals are also just 3-10 SU against division opponents under Gannon, and they’re 4-11 SU when facing teams with winning records with him on the sidelines.
As far as the actual football goes, it’s hard not to start with the Seahawks pass rush. Seattle is currently second in the NFL in Pass Rush Win Rate (52%), and the Arizona offensive line is a little banged up. The Seahawks have the ability to live in the Cardinals backfield in this one. Of course, Kyler Murray’s ability to extend plays helps with some of that. But if Seattle is consistently bringing pressure, the team will eventually get to him — whether that means bringing him down or forcing him to make a mistake through the air.
The Seahawks have also been great against the run this year, ranking fourth in Rush EPA per play allowed (-0.247). That should make things tough on the home team, as James Conner is out for the season with a foot injury. And while Trey Benson has some juice, it could be hard for him to get going against a good defensive line and a swarming group of linebackers.
Seattle’s offense should also be able to do enough here. The Arizona defense has looked great to start the year, and that unit wasn’t the reason the team lost to San Francisco last week. But the Cardinals have also looked vulnerable in the secondary, at times. Well, Sam Darnold should be able to take advantage of any missteps. Darnold was Pro Football Focus’ highest-graded passer (91.9) in Week 3, and he’s currently fourth in the league in Completion Percentage Over Expected (11.6%). It hasn’t taken very long for him to get comfortable in Klint Kubiak’s offense. Also, Darnold was solid in his meeting with Arizona last season, throwing for 235 yards with two touchdowns and no picks.
Seahawks vs. Cardinals Player Props
Lean: Jaxon Smith-Njigba Over 6.5 Receptions (-108)
If I had to take a player prop in this game, I’d go with Smith-Njigba to finish with at least seven receptions. That’s obviously a very high number, but Smith-Njigba has been targeted 29 times this season. And if Seattle wasn’t up so big on New Orleans early in Week 3, he probably would have approached 10 targets — which he did in Weeks 1 and 2.
Our new WR-CB matchup page also paints a nice picture for the emerging star. The Fantasy Points data says that Smith-Njigba’s matchup with Isaac Yiadom is the sixth-most advantageous matchup of the week. With that in mind, I’m not overthinking this. Smith-Njigba had nine catches against the 49ers in Week 1, then he had eight catches against the Steelers in Week 2. With Seattle’s game script being more favorable to the pass-catchers than it was last week, Smith-Njigba should get back to seven or eight catches.
Seahawks vs. Cardinals Pick
If you look at our VSiN betting splits, you’ll see there’s a lot of support for the Seahawks. And it can be scary to be on such a popular side. But there’s a lot that suggests Seattle is the better team on both sides of the ball, and the Seahawks are a little healthier than the Cards. So, even with this game being played in State Farm Stadium, I’m taking Seattle.
Bet: Seahawks ML (-110 – 1.5 units)
