Week 2 NFL Odds
Week 1 is nearly in the books as most teams have turned the page to look at the Week 2 NFL schedule. We still have Monday Night Football between the Vikings and Bears, as previewed by Zachary Cohen, but 30 of the league’s 32 teams are reviewing film, analyzing the matchups, and looking forward to taking the field once again.
Now that we’ve seen what these teams have to offer, we can look at some updated lines for Week 2. DraftKings Sportsbook had numbers out for every week of the NFL season from the schedule release in May, so we had a ballpark idea of where things should be. With no major QB injuries or really any injuries to superstars, we haven’t seen a lot of significant line adjustments, but there have been some.
Like I mentioned in the Week 3 College Football Line Report, we have to figure out what’s real and what’s not from a limited sample size and decide how to use that to our advantage now.
Be sure to keep an eye on our DraftKings NFL Betting Splits and exclusive Circa NFL Betting Splits throughout the week.
Here is the Week 2 NFL Odds Report:
Commanders vs. Packers (-4, 47.5)
Thursday, 8:20 p.m. ET (Amazon Prime)
Both the Commanders and Packers had double-digit wins to kick off the 2025 season, but it is undoubtedly more impressive to beat Detroit in that manner than it is the New York Giants. Green Bay looked very buttoned up, as Jordan Love captained the offense well, including some nice downfield throws, and the defense largely kept a dangerous Lions offense in check. The Commanders did what they were supposed to do and that doesn’t get enough credit sometimes. With the first short week game of the season, the home team has gotten some love here, pushing out to -4 at Circa, but DraftKings is still standing pat at -3.5.
Patriots vs. Dolphins (-1.5, 44)
Sunday, 1 p.m. ET (CBS)
It was not a good week for either one of these teams, as the Patriots began the Mike Vrabel era with a home loss to the Raiders and the Dolphins were thrashed by the Colts in a 33-8 defeat. Tua Tagovailoa looked awful and some speculated that he may have suffered a concussion on a hit during the game. We know he has major concerns about those moving forward, so we’ll keep an ear and eye out for updates. Nevertheless, even though New England lost, Miami’s no-show, literally and figuratively, caused this line to drop a tad and it probably isn’t done.
Jaguars vs. Bengals (-3.5, 50)
Sunday, 1 p.m. ET (CBS)
It was far from pretty for the Bengals, who did start the season 1-0 with a win over the Browns, but if Andre Szmyt could kick, Cleveland likely wins the game. Bettors have sort of responded to that notion, especially with Jacksonville bagging a solid win over the Panthers. Most markets had this line -4 or so on the lookahead number, but a really lackluster performance from Joe Burrow and just two catches for 26 yards for Ja’Marr Chase certainly had bettors looking more towards the underdog. While Jacksonville’s win over Carolina wasn’t dominant, per se, it still showed up a lot better in the box score.
Browns vs. Ravens (-12.5, 45)
Sunday, 1 p.m. ET (CBS)
For a while, it looked as though the Ravens were on their way to a very impressive Week 1 triumph over the Bills. Instead, they found a way to lose a game that they led by 15 points late in the fourth quarter. Assuming there is no discipline for Lamar Jackson for shoving a Bills fan who had hit DeAndre Hopkins in the helmet, Baltimore is going to be a tough team to gauge. That was a game that they put everything into and lost. Cleveland had a near-miss of their own, but they were much feistier than people probably expected. It’s also a big number for a game that could be low-scoring given Cleveland’s defensive prowess. I think it’ll inch down, much like Cleveland’s line did this past week.
Giants vs. Cowboys (-5.5, 44.5)
Sunday, 1 p.m. ET (FOX)
How different would this line look if CeeDee Lamb made that catch and the Cowboys went on to upset the Eagles in Week 1 after all the negative press and discussion with the Micah Parsons/Jerry Jones squabble? Lamb didn’t catch it and the Cowboys did go on to lose, but they looked pretty engaged, which was a big question going into the game. The Giants were one of three teams to fail to score a Week 1 TD. It honestly wouldn’t surprise me if this line rises, as a lot of the goodwill from New York’s preseason showing likely evaporated with how they played against the Commanders.
Rams (-5, 42.5) vs. Titans
Sunday, 1 p.m. ET (CBS)
Cam Ward draws another tough assignment here, this time in the home opener against the visiting Rams. Ward was plagued by drops and honestly played better than his stat line would show against a Broncos team that many believe has the best defense in the NFL. The Rams also have a great defense, as evidenced by the Texans not scoring a touchdown with just three long field goals to show for their efforts. There are 5s and 5.5s out there on this one and I could see this one take on a pro vs. joe, sharp vs. square type of split with some decent value on the Titans getting a head start.
Bills (-7.5, 45.5) vs. Jets
Sunday, 1 p.m. ET (CBS)
Buffalo has a little bit of a quick turnaround since Monday is basically a lost day with the late game against the Ravens. But, the Bills will have a much more enjoyable week of practice and team meetings after finding a way to come back and beat Baltimore. The Jets lost in heartbreaking fashion to Aaron Rodgers and the Steelers on a 60-yard field goal. At this price, or even at -8, Buffalo will be an extremely popular teaser candidate with the option to take them through the key numbers of 3 and 7. Also, the strength of the Jets was supposed to be the defense and Rodgers & Co. hung 34 points on them.
Seahawks vs. Steelers (-3, 41)
Sunday, 1 p.m. ET (FOX)
Speaking of the Steelers, they’ll entertain a Seahawks team that looked pretty putrid on offense to begin the Sam Darnold era. Seattle had just 3.2 yards per carry and Darnold threw for just 150 yards in a 17-13 loss to the 49ers that wasn’t really as close as the score would suggest. Usually, that type of thing leads to some money coming in against a team, as Seattle mustered just 4.6 yards per play and the defense was on the field for nearly 38 minutes of game action. Let’s see if we move off of the key number early in the week. That would be a strong indicator of what the oddsmakers expect.
49ers (-6.5, 43.5) vs. Saints
Sunday, 1 p.m. ET (FOX)
Another early start for a team with some travel, as the 49ers head to NOLA to face the Saints. New Orleans had chances against Arizona, but couldn’t convert them and now faces a stiffer test. What intrigues me here is that this line isn’t all that far off from where the Cardinals closed, but I think we can all agree that the 49ers look like the stronger team on paper. The difference between 5.5 and 6.5 is not all that big in the grand scheme of things, even with 6 being something of a common finishing gap. I bet we see a book or two go to 7 early and see if that entices any Saints love.
Panthers vs. Cardinals (-6.5, 45.5)
Sunday, 4:05 p.m. ET (FOX)
Many Survivor players were able to survive and advance by sweating out the Broncos in Week 1. I think Arizona will be a popular pick here, especially because the Panthers did not look very good in the loss to the Jaguars. Of course, the Cardinals were not terribly impressive against the Saints either, but Kyler Murray and his teammates are back at home and this time it is an East Coast team with a long trek for a game. Much like the 49ers-Saints game, we could see an early 7 pop here, just for the purposes of throwing out a line and seeing who bites. The Panthers are clearly a more palatable option at +7, so it might not be necessary, but sportsbooks do like to know where they stand early in the week.
Broncos (-2.5, 43.5) vs. Colts
Sunday, 4:05 p.m. ET (CBS)
Who would have thought that Daniel Jones would help the Colts make history? Indy scored on all seven of their possessions against the Dolphins in a resounding and lopsided win. Meanwhile, the Broncos had plenty of issues offensively with the Titans. A lot of teams had offensive issues, as the Under was a cash cow in Week 1, at least until we saw more than 80 points scored on MNF. I am very intrigued by this line, as I think most will agree that Jones was an upgrade over Richardson, but Denver is obviously a far stronger opponent. My guess is that this number hangs right around here, which does make Indy a good teaser candidate with the low total and the chance to go through 3 and 7.
Eagles (-1.5, 45.5) vs. Chiefs
Sunday, 4:25 p.m. ET (FOX)
Fox gets the marquee game in the 4 p.m. window here with Eagles vs. Chiefs in a rematch of the Super Bowl. The Eagles survived on Thursday night against the Cowboys, while the Chiefs could not come home from Brazil with a win. They also came home without the services of Xavier Worthy, who dislocated his shoulder on a friendly fire incident with Travis Kelce. Given that Rashee Rice is already out serving a suspension, the Chiefs are shorthanded in terms of playmakers. Hollywood Brown had 16 targets in Week 1. I think with some overriding anti-Chiefs sentiment from the summer, and no reason to back off of it now, Philly has a good chance to become a bigger favorite here.
Buccaneers vs. Texans (-1.5, 44.5)
Monday, 7 p.m. ET (ABC/ESPN)
We get a double dose of MNF in Week 2, as the Texans host the Buccaneers in the first of two tilts. Do we get a flipped favorite scenario here? Houston looked pretty suspect against the Rams, while the Buccaneers battled back for a final-drive win over the division rival Falcons, who swept the two head-to-head meetings last season. Eight different receivers had a catch for CJ Stroud and TEs Dalton Schultz and Cade Stover had seven of the 19 grabs. Nick Chubb looked like a shell of himself with 13 carries for 60 yards. The Bucs don’t have the Rams defense, but they are more explosive offensively. I think TB could very well go off favored here.
Chargers (-3, 45.5) vs. Raiders
Monday, 10 p.m. ET (ESPN)
The nightcap of the Monday Night Football doubleheader is between AFC West rivals, as the Chargers battle the Raiders. LA had a very nice win in a memorable, primetime spot in Brazil, while the Raiders were kind of an afterthought in the early window, even though they picked up a tremendous win against New England in Pete Carroll’s regular season debut. I understand that most of us remain very unsure about the Raiders and the Chargers are more of a proven, projectable commodity, but this line will tell us a lot about what the market thinks of both teams. Furthermore, as a standalone MNF game, public sentiment could have some say in how this number closes, which makes it that much more interesting.
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