The 2025 NFL schedule was officially released on Wednesday, May 14th. We now know exactly what we’re looking at for the upcoming season, so you can expect our NFL betting coverage to ramp up significantly. We’re going to have a ton of written content as the season gets closer and closer, and that includes our VSiN 2025 NFL Betting Guide — which is coming early this summer. We’re also going to be talking NFL regularly on our live VSiN programming. Below, you’re going to find all of the Monday Night Football games for the 2025 NFL season.
Week 1: Minnesota Vikings at Chicago Bears (-1.5, 45.5) – ESPN
How will JJ McCarthy look in his first season under center? We’ll find out in the first Monday Night Football game of the year. Oh, and how about Caleb Williams and the Bears offense in the first year under Ben Johnson? We’ll find out in the first Monday Night Football game of the year. That’s right, we’re going to see the Vikings face the Bears in the MNF opener, and this is a massive NFC North tilt. Last year, Minnesota swept this head-to-head series, covering in one game and pushing in the other. The Vikings have now won seven of their last eight against the Bears. But this is supposed to be a different Chicago team, and it’ll be fun to see if it actually is.
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Week 2: Tampa Bay Buccaneers at Houston Texans (-1.5, 46.5) – ESPN/ABC
Week 2: Los Angeles Chargers (-3, 44.5) at Las Vegas Raiders – ESPN
In the first Monday Night Football doubleheader of the year, the Texans host the Buccaneers in the first game. This has the potential to be a fun one, as Baker Mayfield and CJ Stroud will take to the air to try and lead their teams to victory. And Tampa Bay was 5-3 both straight-up and against the spread on the road last year, so don’t make the mistake of counting the Bucs out at NRG Stadium.
Are the Raiders going to stink again in 2025? We’ll find out pretty quickly. After facing the Patriots in Week 1, Vegas will take on Los Angeles in the second game of a Week 2 MNF doubleheader. The Chargers were a playoff team last season, so they have some expectations heading into the year. But with Pete Carroll now coaching a Raiders team that traded for Geno Smith and drafted Ashton Jeanty, this is the type of game Vegas should be able to win at home.
Week 3: Detroit Lions at Baltimore Ravens (-3.5, 49.5) – ESPN
Last year, these were two of the three best offenses in football, according to EPA per play. So, we could be in for some fireworks in this Monday Night Football matchup. A pretty good argument can be made that Detroit is the more talented team at this point, but bet against Lamar Jackson in primetime at your own peril. The Ravens rarely lose the big ones at night at M&T Bank Stadium.
Week 4: New York Jets at Miami Dolphins (-5.5, 44.5) – ESPN
Week 4: Cincinnati Bengals at Denver Broncos (-2.5, 47.5) – ABC
This doubleheader opens with the Dolphins hosting the Jets. There’s a decent chance New York’s defense is much better than it was a year ago, as Aaron Glenn is a defensive coach and has some talent at his disposal. But how good will the Jets be with Justin Fields under center? Can New York keep up with Tua Tagovailoa and Co.?
The second game features a meeting between the Bengals and Broncos. Last year, Cincinnati beat Denver 30-24 as a 3-point home favorite, but it’ll be interesting to see what happens at altitude. The Bengals were a good road team last year, but the Broncos were 6-2 both SU and ATS at Empower Field. One would also think that Denver will be better with a young team now a year older. But Cincinnati made some changes of its own, and this could be a sleeper for one of the best MNF games of the season.
Week 5: Kansas City Chiefs (-4.5, 47.5) at Jacksonville Jaguars – ESPN/ABC
The Jaguars flamed out last year, but there’s juice with James Gladstone, Liam Coen and Travis Hunter as some exciting new faces in the building. Now, it’ll be interesting to see if Jacksonville can find a way to win some games in 2025. The team had some high expectations heading into last year, and things didn’t work out. But there’s still talent in place, and a new culture could yield some results. And this is the type of game that could put them on the map. The Chiefs are obviously a contender again this year, but it’s hard to go down to Florida and win road games.
Week 6: Buffalo Bills (-5.5, 48.5) at Atlanta Falcons – ESPN
Week 6: Chicago Bears at Washington Commanders (-4.5, 48.5) – ABC
The Falcons were just 4-5 both SU and ATS at home last season, so they didn’t play well enough at home. Well, if that doesn’t change, this is the type of game that can be scary. The Bills were 10-0 at home last season, so they only went 5-5 both SU and ATS on the road. But this is still an explosive offensive team, led by Josh Allen. And the defense is getting better. So, the Bills are going to blow some opponents out this year.
The second game of this doubleheader is narrative heaven. Every time Williams and Jayden Daniels face one another, we’re all going to be sitting around with some popcorn. Daniels got himself in the win column in the first meeting, as the Commanders won 18-15 when they met in Washington last year. But Chicago was a nightmare last season. Let’s see how things look with Johnson calling plays, plus an improved supporting cast.
Week 7: Tampa Bay Buccaneers at Detroit Lions (-3.5, 49.5) – ESPN/ABC
Week 7: Houston Texans at Seattle Seahawks (-1.5, 44.5) – ESPN+
The Buccaneers were one of the few teams that got the Lions last year, as Tampa earned a 20-16 road win as a 7.5-point underdog against Detroit on September 15th. But the Lions had won their previous two meetings by a total of 22 points, and they’ll be out for revenge when they host the Bucs this time around. It’ll be interesting to see how Detroit looks with a new coaching staff, but this team is still stacked.
The second game of the night should be pretty good, as the Seahawks are hoping to do big things with Klint Kubiak, Sam Darnold and Cooper Kupp in on offense. Seattle has always been a tough place to win at night, but you can’t count out Stroud and this Houston team. The Texans have the talent required to take the next step in the AFC this year.
Week 8: Washington Commanders at Kansas City Chiefs (-3.5, 48.5) – ESPN/ABC
This game is going to be fun for all of us. For the longest time, Patrick Mahomes has been viewed as the most talented quarterback in the NFL, and he’s still the best overall signal caller in the league. But in terms of pure talent, Daniels is right there with him. And what he did in his rookie season in Washington was flat-out special. So, seeing these two face off under the Monday night lights will be a real treat. As of right now, it feels like Kansas City’s defense will be the difference. But let’s see what Dan Quinn can do with another offseason in D.C.
Week 9: Arizona Cardinals at Dallas Cowboys (-1.5, 47.5) – ESPN/ABC
There’s a lot of uncertainty with the Cowboys this year, but these are the types of games they should win. When looking at the talent on both rosters, Dallas appears to have a nice little edge over Arizona. Plus, this game will be played at Jerry World. However, the Cardinals did improve in 2024, and Jonathan Gannon has the team on the right path. So, it shouldn’t be surprising to anyone if Arizona ends up looking like the better squad by the time this game actually rolls around.
Week 10: Philadelphia Eagles (-1.5, 45.5) at Green Bay Packers – ESPN/ABC
The Eagles went 2-0 both SU and ATS against the Packers last year. One of those games was played in Brazil, but the second of the two was a 22-10 win in Philadelphia in the postseason. The Eagles are just better than the Packers on both sides of the ball, and it’s hard to see that changing in 2025. However, playing at Lambeau Field could even the playing field. Jordan Love is more comfortable at home, and Matt LaFleur has been great in home games throughout his career.
Week 11: Dallas Cowboys (-1.5, 45.5) at Las Vegas Raiders – ESPN/ABC
These are two of the biggest brands in the sport, so let’s hope this ends up being a good game. It’s actually interesting to see that Dallas is favored on the road, as Vegas should be better right away with some of the new talent on the roster — along with an upgraded coaching staff. Perhaps the oddsmakers are factoring in the fact that Allegiant Stadium will be filled with Cowboys fans. But when looking at some lines for the season, this is one of the rare ones that jumps out as a potential value. This is a game the Raiders will expect to win.
Week 12: Carolina Panthers at San Francisco 49ers (-7, 46.5) – ESPN
These teams haven’t played since the 2022 season, when the 49ers won 37-15 as 6-point favorites in Carolina. San Francisco also won the previous meeting 51-13 in a home game in 2019. Well, the 49ers are big favorites in this game, and they’ll be hoping Christian McCaffrey can run wild against his old team. But San Francisco did have a down year in 2024, and there’s no guarantee the team will improve. And Carolina has the potential to be much better in 2025, so perhaps this will be a better game than we think.
Week 13: New York Giants at New England Patriots (-3, 42.5) – ESPN
Outside of the fact that New York beat New England in two Super Bowls, there’s really not much intrigue with this game. Both of these teams are expected to miss the postseason, and the Giants are viewed as one of the worst teams in the NFL. However, it’s always fun to watch Drake Maye play the quarterback position, and getting to see him in primetime will be a nice change of pace. And who knows? By Week 13, maybe we’ll see Jaxson Dart for the Giants. Honestly, most football fans would settle for Jameis Winston.
Week 14: Philadelphia Eagles (-2.5, 45.5) at Los Angeles Chargers – ESPN/ABC
If the Chargers want to show the world that they should be taken seriously in the AFC, this is the type of game that can help them do that. Los Angeles was great in Jim Harbaugh’s first year on the sidelines, and things are expected to get better in Year 2. But how will the Chargers look against the best of the best? As far as I’m concerned, Philadelphia’s defense could cause some problems for an LA team that still needs to add some talent at the skill positions to help Justin Herbert. But that’s why they play the games.
Week 15: Miami Dolphins at Pittsburgh Steelers (-2.5, 44.5) – ESPN
Look, until there’s some news on the quarterback front, it’s hard to get too excited about any game involving Pittsburgh. Of course, Mike Tomlin is going to field a respectable team, and the Steelers should be near the top of the league in EPA per play allowed in 2025. But they’re not doing anything with Mason Rudolph under center. Wake me up when Aaron Rodgers signs. If he does, this is a game Pittsburgh should win.
Week 16: San Francisco 49ers (-3, 46.5) at Indianapolis Colts – ESPN
The Colts don’t have a lot of primetime games, so they could be juiced up and ready to win when they get their chances. And realistically, if Indianapolis’ quarterback situation is better than it was last year, this is a team that could flirt with a postseason appearance. But just looking at a quarterback room of Anthony Richardson, Daniel Jones and Riley Leonard is far from inspiring. So, on paper, this looks like a really good spot for the 49ers to pick up a road win.
Week 17: Los Angeles Rams (-3, 46.5) at Atlanta Falcons – ESPN
This is another primetime game that appears to be a little lopsided. The Rams are a legitimate Super Bowl contender this year, as they added Davante Adams to an already explosive offense. They also continue to get better on defense. Meanwhile, the Falcons are starting an inexperienced quarterback in Michael Penix Jr., their defense hasn’t been as good as expected and they’re not very comfortable playing at home. So, by the time this game is actually approaching, this line could be very different. But maybe the Falcons will surprise some people. It isn’t out of the question with some of the talent they have on offense, and Penix Jr. can sling it.
