The Thursday Night Football matchup in Week 6 of the 2024 NFL season features the Seattle Seahawks hosting the San Francisco 49ers at Lumen Field. We’ll be diving into all of the primetime games this season, and this one isn’t any different. With that in mind, keep reading for betting odds, picks and player props for this exciting showdown. Also, make sure you head over to the Week 6 NFL Betting Hub for a look at all of our NFL betting content.

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How To Watch 49ers vs. Seahawks

When: Thursday, October 10th at 8:15 pm ET

Where: Lumen Field in Seattle, Washington

Channel: Prime Video

49ers vs. Seahawks Odds

Odds from DraftKings Sportsbook as of Tuesday, October 8th. Make sure you look around for the best prices!

Moneyline: 49ers -185, Seahawks +154

Spread: 49ers -3.5 (-108), Seahawks +3.5 (-112)

Total: Over 47.5 (-112), Under 47.5 (-108)

49ers vs. Seahawks Analysis

Both of these teams will come into this game hungry for a win. San Francisco has dropped three of its last four games, with last week’s home loss as a 7-point favorite against Arizona being especially disappointing. Meanwhile, Seattle also suffered a miserable loss last week, falling as a 7-point home favorite against the New York Giants. The Seahawks have now lost two in a row after having started 3-0. However, this game feels like it’s going to be a little more important to San Francisco. The 49ers are 2-3 on the season. That’s unacceptable for a team with Super Bowl aspirations. And if San Francisco wants a shot at home-field advantage in the playoffs, the wins need to start piling up soon.

The 49ers have had the recent head-to-head success in this matchup. San Francisco has won five games in a row against Seattle, and the team is 4-1 against the spread in those games. Kyle Shanahan will also feel pretty good about how his team matches up with the Seahawks. Seattle’s defense looked great against weak competition early in the year, but the team has an EPA per play allowed of 0.188 over the last two weeks. That’s a higher number than the Rams’ 0.165, which is the worst in football over the course of the entire season. That’s going to be trouble for Seattle, as San Francisco is ninth in the league in EPA per play (0.064) this season.

This really should be a game in which Brock Purdy, PFF’s second-ranked quarterback, gets this passing game going. Just two weeks ago, Jared Goff shredded this secondary to the tune of 18 for 18 on pass attempts with 292 yards and two touchdowns. I also don’t see much preventing Jordan Mason from getting going on the ground. He has rushed for 536 yards and three touchdowns this season, and the 49ers have rushed for at least 169 yards in five straight meetings with the Seahawks.

The 49ers should also be able to get some stops when it matters most here. Over the last four weeks, San Francisco is 13th in the NFL in EPA per play allowed (-0.047), so this unit has still been doing its job. That said, there’s really no reason to believe that the 49ers won’t be able to slow down a Seahawks team that hasn’t quite lived up to expectations on offense this year. Seattle’s offensive numbers are a little skewed from the shootout loss against Detroit.

If you don’t want to lay the points with the 49ers here, another option would be the Over. The Seahawks might have a highly-respected defensive coach, but we haven’t seen a good product on that side of the ball over the last two weeks. Not only did Goff light up the Seahawks, but Daniel Jones did the same. That’s why it’s easy to envision a scenario in which Purdy will put up some big numbers. And if Seattle ends up falling behind at any point, the team will be forced to lean into a pass-heavy approach. Given the weapons Geno Smith has at his disposal, that should mean good things for those looking for a high-scoring affair.

49ers vs. Seahawks Player Props

Brock Purdy Over 1.5 Passing Touchdowns (-117)

The Seahawks have given up two passing touchdowns in back-to-back games, and the most recent game was a little concerning. Jones has struggled all season for New York, but he had no problem marching the Giants down the field and helping his team find the end zone. Well, that makes it hard not to like Purdy to do the same. Purdy also threw for two scores in his most recent meeting with this Seattle defense, so it’s not like we’re asking him to do something we haven’t seen before.

49ers vs. Seahawks Pick

While I like the 49ers in this game, I like the Over a little more. The Over is 33-17-2 when the 49ers have been favored by 3.5 to 9.5 points under Shanahan. The Over is also 4-1 in the five games that the Seahawks have played this season. Also, given what we’ve seen from the 49ers over the last four weeks, you’re probably better off rooting for the offense than rooting for the team to win (and cover).

Lean: Over 47.5 (-109)

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