It’s time for Week 2 of the 2025 NFL season. I strongly suggest you check out the Week 2 NFL Betting Hub, where you’ll find all of the features and picks from my talented co-workers. On top of that, we never stop pumping out good NFL content on our live shows. That’s the beauty of being a subscriber. As a company, we’re relentless in our effort to get you prepared for these games. With that out of the way, let’s get into the fun stuff. Keep reading for my Week 2 NFL best bets and Week 2 NFL player props.
MORE: Check out our Pro Picks page for college football best bets from all of our analysts
New England Patriots at Miami Dolphins – 1:00 pm ET
In Week 1, Kayshon Boutte caught six of his eight targets for 103 yards in a 20-13 loss to the Raiders. All offseason, people billed Stefon Diggs, who signed a three-year, $69 million deal with New England, as the top wideout in Josh McDaniels’ offense. However, Diggs is working his way back from a knee injury, so he’s not exactly healthy right now. And Boutte has a nice rapport with second-year quarterback Drake Maye.
Dating back to last season, Boutte has had at least 95 yards in three of his last four games. And realistically, none of this should be surprising. While there wasn’t a lot of draft equity invested in the former LSU wideout, he’s a former five-star recruit that has tons of talent. And I simply don’t think what we saw last week was a fluke.
After leading the Pats in receptions, targets, yards and air yards, Boutte now heads into a matchup with a miserable Dolphins secondary. That said, I’m playing the Over on 40.5 receiving yards. I’m also putting a little something on Boutte to have 60+ yards at +235.
Bet: Boutte Over 40.5 Receiving Yards (-120) & Boutte Alt Receiving Yards 60+ (+235 – 0.25 units)
Buffalo Bills at New York Jets – 1:00 pm ET
Garrett Wilson is back to life as the No. 1 receiver for the Jets after being kicked to the curb for Davante Adams towards the second half of last season. Wilson is also working with his college quarterback in Justin Fields, and he’s doing so in Tanner Engstrand’s Lions-y offense. All in all, it’s a much better situation for the 25-year-old, who signed a big extension in the offseason. And Wilson delivered right out the gate, catching seven passes for 95 yards and a score against a solid Steelers defense. Now, I like him to do it again, as he’s facing a burnable Bills defense.
Last week, Zay Flowers cooked Buffalo to the tune of seven catches for 143 yards and a touchdown. And I’m not sure the Bills will be throwing anything very different at Wilson.
Christian Benford is a good corner for Buffalo, and he’ll definitely make Wilson work when he’s on him. But Wilson should also see some of Taron Johnson and Dorian Strong. I trust him to create a good amount of separation in those matchups, and I also trust Fields to put the ball on him when he’s open.
Bet: Wilson Over 59.5 Receiving Yards (-110) & Wilson To Score Touchdown (+200 – 0.5 units)
Denver Broncos at Indianapolis Colts – 4:05 pm ET
It’s always important not to overreact to Week 1, yet the odds on this game reflect an overreaction both ways. Denver didn’t look good in a 20-12 win over Tennessee in Week 1, and Indianapolis looked awesome in a 33-8 win over Miami. However, one game shouldn’t completely override everything we saw last season. In 2024, the Broncos were the best team in the league in EPA per play allowed (-0.100), but the Colts were down at 14th (0.005). Denver was also a little better than Indianapolis offensively, as the Broncos had an EPA per play of 0.011 and the Colts were at -0.045.
I know Daniel Jones looked good in the season opener, and Indianapolis has made some nice roster improvements. But I don’t think we’ve seen enough to suggest the Colts are on a level playing field with the Broncos. Just a few weeks ago, Denver was a popular pick to win its division and make noise in the AFC.
I think we’ll see Bo Nix get back on track in this one, and I also see the Broncos defense getting to Jones and Co. The presence of Patrick Surtain II in the secondary should be very scary for an offense led by a mistake-prone quarterback like Jones.
Bet: Broncos ML (-120 – 1.5 units)
Additional Week 1 Best Bets
Commanders +3.5 (-108) vs. Packers, Deebo Samuel Over 4.5 Receptions (-101 – 0.5 units), Jayden Daniels Longest Rush Over 14.5 Yards (-120 – 0.5 units) – CLICK HERE for my vs. Packers Thursday Night Football betting preview!
PARLAY: Cowboys ML vs. Giants & Rams ML vs. Titans (-104 – 1.5 units)
NOTE: I’ll likely add a few more once I dive into the Sunday Night Football and Monday Night Football games!
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2025 Record: 6-3 (+1.82 units)
