It’s time for Week 6 of the 2025 NFL season. I strongly suggest you check out the Week 6 NFL Betting Hub, where you’ll find all of the features and picks from my talented co-workers. On top of that, we never stop pumping out good NFL content on our live shows. That’s the beauty of being a subscriber. As a company, we’re relentless in our effort to get you prepared for these games. With that out of the way, let’s get into the fun stuff. Keep reading for my Week 6 NFL best bets and Week 6 NFL player props.
MORE: Check out our Pro Picks page for college football best bets from all of our analysts
Denver Broncos vs. New York Jets – 9:30 am ET (Tottenham Hotspur Stadium in London)
Seattle Seahawks at Jacksonville Jaguars – 1:00 pm ET
I love the Broncos to handle their business against the Jets in London. Denver’s defense is up to third in the NFL in EPA per play allowed (-0.074), making it hard to imagine New York consistently moving the ball. Plus, the Broncos offense hasn’t been great to start the year, but the team has looked much better over the last few weeks. And having a Sean Payton offense against a Jets defense that is 29th in the NFL in EPA per play allowed (0.169) feels like a massive mismatch. And generally speaking, Denver’s coaching staff going to work against New York’s coaching staff will be quite the mismatch — especially in an international game that makes the task at hand more difficult. However, instead of laying the 7.5, I’m playing the moneyline and pairing it with Seattle on an alternate number.
The Jaguars might be coming off a big win over the Chiefs, but they have a short week to turn around and face a good Seahawks squad. Seattle is in the same tier as Jacksonville when looking at overall EPA per play at RBSDM, and the Seahawks should make for a touch matchup for the Jags. Seattle likely won’t get diced up on the ground, as Mike Macdonald is a great defensive mind and should have his team ready for the Travis Etienne attack. And while Trevor Lawrence made some big plays against Kansas City, he’s still looking a little shaky as a passer. That said, the Seahawks should be able to cover a pretty inflated alternate spread. This is a game they could win outright.
PARLAY: Broncos ML & Seahawks +8.5 (-167 – 1.5 units)
Los Angeles Chargers at Miami Dolphins – 1:00 pm ET
Quentin Johnston’s matchup with Jack Jones pops up as a major advantage on our WR-CB Matchup Report (powered by Fantasy Points), which is good considering I was already looking for ways to get involved in this game. This Dolphins defense is 31st in the NFL in EPA per play allowed (0.197) and 30th in Dropback EPA per play allowed (0.305). This passing defense just isn’t reliable whatsoever, and SumerSports has Miami with the most explosive plays allowed in the league this season. That makes this a dream matchup for Johnston, who is a big play waiting to happen. Johnston, who has 377 yards and four scores this season, has had at least a 33-yard catch in four of the five games Los Angeles has played this year. And one big one like that would go a long way towards him reaching 56 yards, which he has also done in four of the five games he has played this year.
This total just feels low in a game in which Justin Herbert will have the green light to launch. I’m also taking a shot on Johnston to find the end zone.
Bet: Johnston Over 55.5 Receiving Yards (-118 – 1.5 units) & Johnston Anytime TD (+175 – 0.5 units)
Dallas Cowboys at Carolina Panthers – 1:00 pm ET
Young didn’t go Over his passing yard prop last week, but he did throw for two scores. And overall, the 24-year-old played well after a shaky start to the game. Now Young is going to be up against a Cowboys team with an awesome offense and miserable passing defense. That feels like a recipe for a big day in the box score — especially with Young playing at home, where he has been much better early in his career.
Dallas gave up 450 passing yards to Russell Wilson in Week 2, 298 passing yards to Caleb Williams in Week 3, 337 passing yards to Jordan Love in Week 4, and 283 passing yards to Fields in Week 5. Realistically, the only thing I can see keeping Young from having a big day is another huge game from Rico Dowdle. His 206 rushing yards against Miami last week made it hard for Young to put up big yardage himself, and the former Dallas running back could be running angry here.
Bet: Young Over 221.5 Passing Yards (-115 – 1.5 units) & Young Over 1.5 Passing Touchdowns (+120 – 0.5 units)
Additional Week 6 Best Bets
SAME-GAME PARLAY: Eagles ML, Jalen Hurts 150+ Passing Yards, A.J. Brown 40+ Receiving Yards (-121) – CLICK HERE for my Eagles-Giants Thursday Night Football betting preview!
Bengals-Packers Over 44 (-110)
Bears +4.5 (-105 – 1.5 units) & Bears ML (+190 – 0.5 units) vs. Commanders – I locked in this price earlier than usual, but I’ll have a write-up for this game available on Sunday.
I’ll likely add some more later in the week. Keep an eye on the VSiN picks page!
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2025 Record: 34-31 (+2.96 units)
