It’s time for Week 6 of the 2026 NFL season. I strongly suggest you check out the Week 6 NFL Betting Hub, where you’ll find all of the features and picks from my talented co-workers. On top of that, we never stop pumping out good NFL content on our live shows. That’s the beauty of being a subscriber. As a company, we’re relentless in our effort to get you prepared for these games. With that out of the way, let’s get into the fun stuff. Keep reading for my Week 6 NFL best bets and Week 6 NFL player props.

MORE: Check out our Pro Picks page for NFL best bets from all of our analysts

Houston Texans vs. Jacksonville Jaguars – 9:30 am ET (London)

I genuinely believe the Texans are a good team, and I think last week was a big step in the right direction. Houston also went out and acquired Marvin Harrison Jr., adding some real size and talent at wideout. Once the defense stabilizes, we should be talking about a borderline playoff team again, and that does feel more like a “once” than an “if.” Having said that, Jacksonville is currently a Tier 2 team in Net EPA/Play at RBSDM, and Houston is barely a Tier 4 team. There’s a big difference between where these teams currently rank statistically, with the Jaguars being better on both sides of the ball.

Jacksonville also happens to be playing a second consecutive game in London. The Jaguars have had the luxury of getting comfortable in their second home, and this trip has to feel like a breeze to them at this point. That’s a big advantage for Jacksonville heading into this game, even if the travel overseas continues to get easier and easier for players.

The Jaguars have also been very reliable under Liam Coen as favorites. In such games, they’re 11-1 straight-up and have won those contests by 14.1 points per game. Meanwhile, the Texans are 1-6 SU and 3-4 against the spread against teams with winning percentages of 75% or higher with DeMeco Ryans on the sidelines. And when facing teams with winning percentages of 25% or worse, Coen is 3-0 both SU and ATS with the Jaguars.

Bet: Jaguars -2.5 (+100)

Chicago Bears at Atlanta Falcons – 1:00 pm ET

I thought the Falcons would handle their business against the Lamar Jackson-less Ravens last week, and they ended up suffering a disappointing loss. However, I’m still pretty high on this Atlanta team. The Falcons are seventh in the NFL in EPA/Play Allowed (-0.035), profiling as one of the best defensive teams in football. That said, Caleb Williams or no Caleb Williams, Atlanta should have a decent chance of getting some key stops in this game. But can Chicago do the same?

The Bears are back down to 20th in the NFL in EPA/Play Allowed (0.000) after having been torched by the Packers last week. And that performance was really what I was waiting for from a Chicago defense we saw struggle against Carolina in Week 1.

I’m a huge fan of Ben Johnson and his offense, but I think the Bears have one of the worst defenses in football. That should mean the Falcons will be in this one, and just hanging around makes this a worthwhile dart throw at +140.

Bet: Falcons ML (+140)

New Orleans Saints at New York Giants – 1:00 pm ET

I’m going back to this for a third week in a row. Of course, the numbers were way more favorable in Weeks 4 and 5, but I’m still happy with plus-money odds. Winston threw 29 times for 250 yards and three touchdowns two weeks ago. Then, in an overtime game against the Commanders last week, Winston threw 54 times and finished with 326 yards and another three scores. After two weeks of having Winston play conservative football, the 30-30 pre-LASIK version of the quarterback has been unleashed.

Winston now gets a crack at a defense ranked 26th in Dropback EPA/Play Allowed (0.169). That’s right below the Washington defense we just saw Winston light up. I think we’ll see another multi-touchdown game.

Bet: Winston Over 1.5 Passing Touchdowns (+116)

Additional Week 6 Best Bets

Broncos ML (+130 – 1.5 units) & Jaylen Waddle Over 46.5 Receiving Yards (-115) vs. Seahawks – Check out my Thursday Night Football Preview!

PARLAY: Browns Alt +10.5 vs. Ravens & Patriots ML vs. Jets (-127 – 1.5 units)

Week 5 Picks

Buccaneers +8.5 (-108) vs. Cowboys
Eagles +8 (-110 – 1.5 units) vs. Jaguars
Eagles ML (+320 – 0.5 units) vs. Jaguars
Vikings ML (-130) vs. Saints
Jones Over 71.5 Rushing Yards (-110) vs. Saints
Packers ML (+120) vs. Bears
Doubs Over 50.5 Receiving Yards (-115)vs. Raiders
PARLAY: Bengals ML vs. Dolphins & Texans ML vs. Titans (-145)
PARLAY: Brown Alt +8.5 vs. Jets & 49ers Alt +8.5 vs. Seahawks (-135)
Winston Over 1.5 Passing Touchdowns (+162) vs. Commanders
Falcons -3 (-118) vs. Ravens
Rams -3.5 (+100) vs. Bills

2026 NFL Record: 31-25 (+10.07 units)

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Zachary Cohen
Zach has been writing about betting since he was a student at the University of Wisconsin, which is when he started working with StatFox — and contributing to the weekly Platinum Sheet. His work has since been featured for brands like Covers, Sports Illustrated and Tennis Channel. Zach is extremely passionate about the NBA, but he does a bit of everything and has found a niche as a tennis handicapper. Outside of work, Zach likes watching bad comedies and getting shots up in empty gyms — or spending time with his wife and dog.