2023 San Francisco 49ers schedule, betting odds, and predictions


49ers have Super Bowl aspirations despite rough 2023 schedule

It’s not yet clear who will be playing quarterback for the San Francisco 49ers this season, but it probably doesn’t matter. Whether it’s Sam Darnold, Brock Purdy or Trey Lance, San Francisco has elite talent around the man under center and this is likely the best team in the NFC, on paper. The 49ers do have a pretty difficult schedule this season, but that’s not going to phase this team much. San Francisco is loaded on both sides of the ball and should once again be a Super Bowl contender.


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San Francisco 49ers betting odds

(odds from DraftKings as of May 12, 5:00 p.m. PT)

Season Win Total Odds: 10.5 (-120/+100)
Super Bowl Odds: +900
NFC Champion: +380
NFC West Champion: -150

Last season: 13-4, 3rd in NFC West

Key additions: DL Javon Hargrave, DE Clelin Ferrell, QB Sam Darnold, OT Matt Pryor, OG Jon Feliciano, CB Isaiah Oliver, K Zane Gonzalez, CB Myles Hartsfield, S Ji’Ayir Brown*, K Jake Moody*, TE Cameron Latu*

Key losses: OT Mike McGlinchey, S Jimmie Ward, QB Jimmy Garoppolo, DE Samson Ebukam, CB Emmanuel Moseley, DL Hassan Ridgeway, LB Azeez Al-Shaair, DE Charles Omenihu

* – drafted

2023 San Francisco 49ers schedule

  • Week 1: @ Pittsburgh Steelers (SF -3, Total: 42)
  • Week 2: @ Los Angeles Rams (SF -3)
  • Week 3: vs. New York Giants (SF -4.5)
  • Week 4: vs. Arizona Cardinals (SF -9.5)
  • Week 5: vs. Dallas Cowboys (SF -2)
  • Week 6: @ Cleveland Browns (SF -1)
  • Week 7: @ Minnesota Vikings (SF -1)
  • Week 8: vs. Cincinnati Bengals (SF -1)
  • Week 9: BYE WEEK
  • Week 10: @ Jacksonville Jaguars (SF -1)
  • Week 11: vs. Tampa Bay Buccaneers (SF -7.5)
  • Week 12: @ Seattle Seahawks (SF -1.5)
  • Week 13: @ Philadelphia Eagles (PHI -2.5)
  • Week 14: vs. Seattle Seahawks (SF -3.5)
  • Week 15: @ Arizona Cardinals (SF -6.5)
  • Week 16: vs. Baltimore Ravens (SF -3)
  • Week 17: @ Washington Commanders (SF -3)
  • Week 18: vs. Los Angeles Rams (SF -6)

(odds from DraftKings Sportsbook)

San Francisco 49ers schedule this year

The 49ers have plenty of games on national television this year, but one of the ones everybody will be looking forward to is the Week 5 meeting with the Cowboys. That’s one of the most classic rivalries in the sport, so it’s one that’s perfectly suited for primetime. As far as the rest of the schedule goes, San Francisco doesn’t exactly have the easiest set of games. The 49ers’ schedule is loaded with teams that have realistic playoff aspirations, but a team as talented as San Francisco won’t worry about that too much. Even with a little uncertainty at quarterback, you’d expect this group to figure it out. However, the team does have a few short rest spots this year. 

San Francisco 49ers schedule analysis

For more on the 49ers schedule, here’s what Matt Youmans and Wes Reynolds had to say on VSiN Tonight following the NFL’s official release: