Today we have a loaded slate of midweek MLB action on tap with 15 games to choose from. Let’s examine where smart money is leaning for a trio of matchups using our VSiN MLB Betting Splits, which are updated every 5 minutes and come directly from DraftKings and Circa Sports.
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1:05 p.m. ET: Kansas City Royals at Washington Nationals (-135, 10.5)
The Nationals (39-35) have taken the first two games of this three-game Interleague series, winning the opener 7-3 as -140 home favorites and then winning again yesterday 6-4 as -145 home favorites.
In this afternoon’s series finale, the Royals (29-45) hand the ball to righty Luinder Avila (1-3, 6.19 ERA) and the Nationals counter with fellow righty Zack Littell (6-5, 5.32 ERA).
This line opened with Washington listed as a -125 home favorite and Kansas City a +105 road dog.
Sharps are riding the hot hand and have gotten down on the Nationals to complete the sweep, pushing Washington up from -125 to -135.
At DraftKings, the Nationals are taking in 82% of moneyline bets and 84% of moneyline dollars, a one-way Pro and Joe bet split in their favor.
Above .500 home favorites priced -140 or less facing a sub .500 opponent, like the Nats here, are 37-24 (61%) with a 10% ROI this season. Home favorites -140 or less facing an opponent who missed the playoffs the previous season are 133-88 (60%) with a 9% ROI this season.
Interleague home favorites off a win priced -150 or less receiving line movement in their favor are 77-38 (67%) with a 19% ROI since 2025.
Washington has the edge offensively, posting a .424 slugging percentage with 405 runs scored compared to Kansas City posting a .378 slugging percentage and only 295 runs scored.
Avila has posted an 8.44 ERA in three June starts, giving up 10 earned runs in 10.2 innings pitched. The Royals are 4-9 in his 13 appearances this season.
On the other hand, the Nationals are 5-1 in Littell’s last six starts. He is 3-0 with a 3.42 ERA during the day compared to 3-5 with a 6.38 ERA at night.
3:40 p.m. ET: Los Angeles Angels at Arizona Diamondbacks (-170, 9.5)
This is the rubber match of a three-game Interleague series.
The Diamondbacks (37-36) won the opener 4-3, taking care of business as -150 home favorites. Then the Angels (30-44) bounced back with a 7-0 victory yesterday, coming through as a -110 road pick’em.
In this late afternoon series finale, the Angels start lefty Sam Aldegheri (2-1, 2.12 ERA) and the Diamondbacks turn to fellow southpaw Eduardo Rodriguez (5-2, 2.55 ERA).
This line opened with Arizona listed as a -165 home favorite and Los Angeles a +145 road dog.
Sharps have quietly laid the chalk with the Snakes at home, pushing Arizona up from -165 to -170 and even as high as -175 at some shops.
At DraftKings, Arizona is taking in 76% of moneyline bets and 94% of moneyline dollars. At Circa, the Diamondbacks are receiving 86% of moneyline bets and over 95% of moneyline dollars. Both books are showing a “low bets, higher dollars” sharp split in favor of the home chalk.
Pros have also targeted the Diamondbacks on the run-line (-1.5 at +125), as Arizona is receiving 60% of spread bets and a 82% of spread dollars at DraftKings.
Arizona is 10-2 in Rodriguez’s last 12 starts. He is 3-1 with a 1.93 ERA at home.
Meanwhile, Aldegheri has posted a 5.40 ERA on the road compared to 1.76 at home.
The Diamondbacks are hitting .264 against lefties (3rd best in MLB) while the Angels are only hitting .234 (21st).
Arizona is 22-15 at home, the 7th best home team in MLB. Los Angeles is just 13-24 on the road, tied for the 3rd worst road team in MLB.
6:45 p.m. ET: Toronto Blue Jays at Boston Red Sox (-130, 9.5)
The Blue Jays (35-38) won last night’s series opener 6-1, cashing as -120 road favorites.
In tonight’s rematch, the Blue Jays send out righty Max Scherzer (1-4, 10.23 ERA) and the Red Sox (29-41) go with lefty Jake Bennett (1-2, 5.28 ERA).
This line opened with Boston listed as a -120 home favorite and Toronto a +100 road dog.
Sharps have sided with the Red Sox to bounce back with a win at Fenway, driving Boston up from -120 to -130.
At DraftKings, the Red Sox are receiving only 52% of moneyline bets but 78% of moneyline dollars, a notable “low bets, higher dollars” sharp split indicating an undecided public but also heavy wiseguy money in their favor.
Home favorites -140 or less, like the Red Sox tonight, are 200-146 (58%) with a 4% ROI this season.
Home favorites with line movement in their favor in the second game of a series after losing the opener are 16-9 (64%) with a 5% ROI this season. Sweet spot home favorites priced between -125 and -140 who made the playoffs the previous season facing an opponent who also made the playoffs the previous season are 49-23 (68%) with a 20% ROI since 2025.
Toronto is 0-5 in Scherzer’s last five starts. He has posted a 14.40 ERA in his last four starts, allowing 22 earned runs in 14 innings pitched.
Meanwhile, the Blue Jays are only hitting .218 against lefties, ranking 28th in MLB.
